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HRH4 [plasma membrane]
Stable Identifier
R-HSA-390910
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Histamine H4 receptor, RecName: Full=Histamine H4 receptor; Short=HH4R; AltName: Full=G-protein coupled receptor 105; AltName: Full=GPRv53; AltName: Full=SP9144; AltName: Full=AXOR35; AltName: Full=Pfi-013;
GN Name=HRH4; Synonyms=GPCR105;
OS Homo sapiens, HRH4_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HRH4:Hist [plasma membrane] (Homo sapiens)
HRH4 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HRH4:Hist [plasma membrane] (Homo sapiens)
HRH4 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HRH4:Hist [plasma membrane] (Homo sapiens)
HRH4 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HRH4:Hist [plasma membrane] (Homo sapiens)
HRH4 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HRH4:Hist [plasma membrane] (Homo sapiens)
HRH4 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HRH4:Hist [plasma membrane] (Homo sapiens)
HRH4 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Amine ligand-binding receptors (Homo sapiens)
Histamine receptors (Homo sapiens)
HRH4 binds Hist (Homo sapiens)
HRH4 [plasma membrane] (Homo sapiens)
HRH4:Hist [plasma membrane] (Homo sapiens)
HRH4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H3N8 HRH4
Gene Names
HRH4, GPCR105
Chain
chain:1-390
Reference Genes
BioGPS Gene:59340 HRH4
COSMIC (genes):HRH4 HRH4
CTD Gene:59340 HRH4
dbSNP Gene:59340 HRH4
ENSEMBL:ENSG00000134489.7 HRH4
HGNC:17383 HRH4
KEGG Gene (Homo sapiens):59340 HRH4
Monarch:59340 HRH4
NCBI Gene:59340 HRH4
OMIM:606792 HRH4
UCSC:Q9H3N8 HRH4
Reference Transcript
RefSeq:NM_001143828.1 HRH4
RefSeq:NM_001160166.1 HRH4
RefSeq:NM_021624.3 HRH4
Other Identifiers
11737888_a_at
11737889_a_at
16851618
221169_PM_s_at
221169_s_at
221170_PM_at
221170_at
3782196
3782197
3782198
3782200
3782202
3782203
3782204
3782205
3782206
3782207
3782208
59340
8020684
A_14_P112471
A_14_P121819
A_23_P386310
GE79694
GO:0004930
GO:0004969
GO:0004993
GO:0005886
GO:0006954
GO:0007165
GO:0007186
GO:0007187
GO:0007197
GO:0007204
GO:0007268
GO:0008150
GO:0016020
GO:0016021
GO:0016907
GO:0023052
GO:0030425
GO:0030594
GO:0043408
GO:0045202
GO:0060089
GO:0098664
HMNXSV003019379
ILMN_1810424
PH_hs_0028113
TC18000111.hg
g11055987_3p_a_at
g13094918_3p_at
Participates
as an input of
HRH4 binds Hist (Homo sapiens)
as a component of
HRH4:Hist [plasma membrane] (Homo sapiens)
Inferred To
LOC116411746 [plasma membrane]
(Xenopus tropicalis)
gar-2 [plasma membrane]
(Caenorhabditis elegans)
gar-3 [plasma membrane]
(Caenorhabditis elegans)
LOC428525 [plasma membrane]
(Gallus gallus)
HRH4 [plasma membrane]
(Bos taurus)
HRH4 [plasma membrane]
(Canis familiaris)
HRH4 [plasma membrane]
(Xenopus tropicalis)
mAChR-B [plasma membrane]
(Drosophila melanogaster)
Homologues of HRH4 [plasma membrane]
(Caenorhabditis elegans)
Homologues of HRH4 [plasma membrane]
(Drosophila melanogaster)
Homologues of HRH4 [plasma membrane]
(Xenopus tropicalis)
mAChR-A [plasma membrane]
(Drosophila melanogaster)
LOC100334962 [plasma membrane]
(Danio rerio)
Hrh4 [plasma membrane]
(Mus musculus)
Hrh4 [plasma membrane]
(Rattus norvegicus)
gar-1 [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001137300.1
,
NP_067637.2
,
NP_001153638.1
ZINC - World Drugs
HRH4_HUMAN
Guide to Pharmacology - Targets
265
OpenTargets
ENSG00000134489
ZINC - FDA approved
HRH4_HUMAN
ZINC - Substances
HRH4_HUMAN
ZINC - Biogenic
HRH4_HUMAN
ZINC target
Q9H3N8
PRO
Q9H3N8
ZINC - Investigational
HRH4_HUMAN
ZINC - Metabolites
HRH4_HUMAN
GeneCards
Q9H3N8
HPA
ENSG00000134489-HRH4
Ensembl
ENST00000426880
,
ENSP00000402526
,
ENSP00000256906
,
ENST00000256906
,
ENSG00000134489
Pharos - Targets
Q9H3N8
ZINC - Predictions - Purchasable
HRH4_HUMAN
HMDB Protein
HMDBP08132
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