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Striated Muscle Contraction
Stable Identifier
R-HSA-390522
DOI
10.3180/REACT_16935.1
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Muscle contraction (Homo sapiens)
Striated Muscle Contraction (Homo sapiens)
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Striated muscle contraction is a process whereby force is generated within striated muscle tissue, resulting in a change in muscle geometry, or in short, increased force being exerted on the tendons. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle composed of myofibrils, containing repeating units called sarcomeres, in which the contractile myofibrils are arranged in parallel to the axis of the cell, resulting in transverse or oblique striations observable at the level of the light microscope.
Here striated muscle contraction is represented on the basis of calcium binding to the troponin complex, which exposes the active sites of actin. Once the active sites of actin are exposed, the myosin complex bound to ADP can bind actin and the myosin head can pivot, pulling the thin actin and thick myosin filaments past one another. Once the myosin head pivots, ADP is ejected, a fresh ATP can be bound and the energy from the hydrolysis of ATP to ADP is channeled into kinetic energy by resetting the myosin head. With repeated rounds of this cycle the sarcomere containing the thin and thick filaments effectively shortens, forming the basis of muscle contraction.
Literature References
PubMed ID
Title
Journal
Year
13175187
Measurement of muscle striations in stretch and contraction
NIEDERGERKE, R
,
HUXLEY, AF
J Physiol
1954
15173218
The sliding filament model: 1972-2004
Cooke, R
J Gen Physiol
2004
13165697
Structural changes in muscle during contraction; interference microscopy of living muscle fibres
NIEDERGERKE, R
,
HUXLEY, AF
Nature
1954
Regulatory Mechanisms of Striated Muscle Contraction
Ohtsuki, I
,
Ebashi, S
2007
15173217
The early history of the biochemistry of muscle contraction
Szent-Györgyi, AG
J Gen Physiol
2004
Participants
Events
Calcium Binds Troponin-C
(Homo sapiens)
Myosin Binds ATP
(Homo sapiens)
ATP Hydrolysis By Myosin
(Homo sapiens)
Release Of ADP From Myosin
(Homo sapiens)
Participates
as an event of
Muscle contraction (Homo sapiens)
Event Information
Go Biological Process
muscle filament sliding (0030049)
Orthologous Events
Striated Muscle Contraction (Bos taurus)
Striated Muscle Contraction (Canis familiaris)
Striated Muscle Contraction (Gallus gallus)
Striated Muscle Contraction (Mus musculus)
Striated Muscle Contraction (Rattus norvegicus)
Striated Muscle Contraction (Sus scrofa)
Authored
Gillespie, ME (2009-02-10)
Reviewed
Rush, MG (2008-01-11)
Created
Gillespie, ME (2009-02-10)
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