Reactome | Myosin Binds ATP

Myosin Binds ATP

Stable Identifier

R-HSA-390598

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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A molecule of ATP binds to the large cleft on the side of the myosin head farthest from the actin filament and immediately causes a slight change in the conformation of the domains that make up the actin-binding site. This reduces the affinity of the myosin head for actin and allows it to move along the filament.

Literature References

PubMed ID	Title	Journal	Year
10747208	Regulation of contraction in striated muscle Gordon, AM, Homsher, E, Regnier, M	Physiol Rev	2000
	Regulatory Mechanisms of Striated Muscle Contraction Ohtsuki, I, Ebashi, S		2007