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Myosin Binds ATP
Stable Identifier
R-HSA-390598
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Muscle contraction (Homo sapiens)
Striated Muscle Contraction (Homo sapiens)
Myosin Binds ATP (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
A molecule of ATP binds to the large cleft on the side of the myosin head farthest from the actin filament and immediately causes a slight change in the conformation of the domains that make up the actin-binding site. This reduces the affinity of the myosin head for actin and allows it to move along the filament.
Literature References
PubMed ID
Title
Journal
Year
10747208
Regulation of contraction in striated muscle
Gordon, AM
,
Homsher, E
,
Regnier, M
Physiol Rev
2000
Regulatory Mechanisms of Striated Muscle Contraction
Ohtsuki, I
,
Ebashi, S
2007
Participants
Input
x 2
ATP [cytosol]
Calcium Bound Sarcomere Protein Complex [cytosol]
(Homo sapiens)
Output
ATP:Calcium Bound Sarcomere Protein Complex [cytosol]
(Homo sapiens)
Participates
as an event of
Striated Muscle Contraction (Homo sapiens)
Orthologous Events
Myosin Binds ATP (Bos taurus)
Myosin Binds ATP (Canis familiaris)
Myosin Binds ATP (Gallus gallus)
Myosin Binds ATP (Mus musculus)
Myosin Binds ATP (Rattus norvegicus)
Myosin Binds ATP (Sus scrofa)
Authored
Gillespie, ME (2003-07-01)
Reviewed
Rush, MG (2008-01-11)
Created
Gillespie, ME (2009-02-10)
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