FAR1 reduces PalmCoA to HXOL

Stable Identifier
R-HSA-390425
Type
Reaction [transition]
Species
Homo sapiens
Compartment
peroxisomal matrix
Synonyms
palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1]
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FAR1 reduces PalmCoA to HXOL
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Peroxisomal fatty acyl-CoA reductase 1 (FAR1) catalyzes the reaction of palmitoyl-CoA (PalmCoA) and 2 NADPH + 2 H+ to form hexadecanol (HXOL), CoASH, and 2 NADP+. As judged from mRNA levels, FAR1 is widely expressed in the body (Cheng and Russell 2004).

Literature References
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
oxidoreductase activity of FAR1 [peroxisomal membrane]
Physical Entity
FAR1 [peroxisomal membrane]
Activity
oxidoreductase activity (0016491)
Orthologous Events
FAR1 reduces PalmCoA to HXOL (Bos taurus)
FAR1 reduces PalmCoA to HXOL (Caenorhabditis elegans)
FAR1 reduces PalmCoA to HXOL (Canis familiaris)
FAR1 reduces PalmCoA to HXOL (Danio rerio)
FAR1 reduces PalmCoA to HXOL (Dictyostelium discoideum)
FAR1 reduces PalmCoA to HXOL (Drosophila melanogaster)
FAR1 reduces PalmCoA to HXOL (Mus musculus)
FAR1 reduces PalmCoA to HXOL (Rattus norvegicus)
FAR1 reduces PalmCoA to HXOL (Sus scrofa)
FAR1 reduces PalmCoA to HXOL (Xenopus tropicalis)
Cross References
Rhea
Authored
D'Eustachio, P  (2009-03-16)
Reviewed
Jassal, B  (2009-02-27)
Created
D'Eustachio, P  (2009-02-07)