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QRFPR [plasma membrane]
Stable Identifier
R-HSA-389504
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Orexigenic neuropeptide QRFP receptor, RecName: Full=Orexigenic neuropeptide QRFP receptor; AltName: Full=G-protein coupled receptor 103; AltName: Full=SP9155; AltName: Full=AQ27;
GN Name=GPR103;
OS Homo sapiens, QRFPR_HUMAN, GPR103, SP9155
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
QRFPR:QRFP [plasma membrane] (Homo sapiens)
QRFPR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
QRFPR:QRFP [plasma membrane] (Homo sapiens)
QRFPR [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
QRFPR:QRFP [plasma membrane] (Homo sapiens)
QRFPR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
QRFPR:QRFP [plasma membrane] (Homo sapiens)
QRFPR [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
QRFPR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
QRFPR:QRFP [plasma membrane] (Homo sapiens)
QRFPR [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Orexin and neuropeptides FF and QRFP bind to their respective receptors (Homo sapiens)
The orphan QRFP receptor can bind neuropeptide QRFP (Homo sapiens)
QRFPR [plasma membrane] (Homo sapiens)
QRFPR:QRFP [plasma membrane] (Homo sapiens)
QRFPR [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96P65 QRFPR
Gene Names
QRFPR, GPR103
Chain
chain:1-431
Reference Genes
BioGPS Gene:84109 QRFPR
COSMIC (genes):QRFPR QRFPR
CTD Gene:84109 QRFPR
dbSNP Gene:84109 QRFPR
ENSEMBL:ENSG00000186867 QRFPR
HGNC:15565 QRFPR
KEGG:hsa:84109 QRFPR
Monarch:84109 QRFPR
NCBI Gene:84109 QRFPR
OMIM:606925 QRFPR
UCSC:Q96P65 QRFPR
Reference Transcript
RefSeq:NM_198179.2 QRFPR
Other Identifiers
11742101_at
1555533_PM_at
1555533_at
16979468
2783979
2783980
2783981
2783982
2783984
2783986
2783987
2783989
2783990
2783991
2784005
2784006
2784007
67682_at
8102608
8102610
84109
A_23_P92467
GE574331
GO:0004930
GO:0004983
GO:0005515
GO:0005886
GO:0007186
GO:0007218
GO:0016020
GO:0032870
GO:0042277
GO:0060089
HMNXSV003042832
Hs2Affx.1.354.S1_3p_at
ILMN_2221336
PH_hs_0032901
TC04001513.hg
Participates
as an input of
The orphan QRFP receptor can bind neuropeptide QRFP (Homo sapiens)
as a member of
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
as a component of
QRFPR:QRFP [plasma membrane] (Homo sapiens)
Inferred To
GPR103 [plasma membrane]
(Gallus gallus)
QRFPR [plasma membrane]
(Bos taurus)
QRFPR [plasma membrane]
(Canis familiaris)
QRFPR [plasma membrane]
(Sus scrofa)
qrfpr [plasma membrane]
(Xenopus tropicalis)
Qrfprl [plasma membrane]
(Mus musculus)
Qrfprl [plasma membrane]
(Rattus norvegicus)
SIFaR [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_937822.2
Guide to Pharmacology - Targets
333
ENSEMBL
ENST00000394427
,
ENSP00000377948
OpenTargets
ENSG00000186867
ZINC - Substances
QRFPR_HUMAN
ZINC target
Q96P65
PRO
Q96P65
GlyGen
Q96P65
PDB
8WZ2
HPA
ENSG00000186867-QRFPR
Pharos - Targets
Q96P65
ZINC - Predictions - Purchasable
QRFPR_HUMAN
HMDB Protein
HMDBP07961
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9P121-3 NTM
0.556
3
UniProt:P48165 GJA8
1
GJA8 [endoplasmic reticulum membrane]
(R-HSA-190702)
0.556
3
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