The orphan QRFP receptor can bind neuropeptide QRFP

Stable Identifier
R-HSA-389424
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The orphan QRFP receptor (SP9155) (Lee DK et al, 2001) shares a high sequence homology with the neuropeptide FF receptor. It mediates the activity of neuropeptide QRFP (Jiang Y et al, 2003), which is suspected to have orexigenic activity, via the G alpha-q/11 subunit (Langmead CJ et al, 2000).

Literature References
PubMed ID Title Journal Year
12714592 Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155

Jiang, Y, Luo, L, Gustafson, EL, Yadav, D, Laverty, M, Murgolo, N, Vassileva, G, Zeng, M, Laz, TM, Behan, J, Qiu, P, Wang, L, Wang, S, Bayne, M, Greene, J, Monsma F, Jr, Zhang, FL

J Biol Chem 2003
11030716 Characterization of the binding of [(125)I]-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor

Langmead, CJ, Szekeres, PG, Chambers, JK, Ratcliffe, SJ, Jones, DN, Hirst, WD, Price, GW, Herdon, HJ

Br J Pharmacol 2000
11574155 Discovery and mapping of ten novel G protein-coupled receptor genes

Lee, DK, Nguyen, T, Lynch, KR, Cheng, R, Vanti, WB, Arkhitko, O, Lewis, T, Evans, JF, George, SR, O'Dowd, BF

Gene 2001
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created