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KISS1(68-121) [extracellular region]
Stable Identifier
R-HSA-389043
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Metastin
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
KISS1R:KISS1(68-121) [plasma membrane] (Homo sapiens)
KISS1(68-121) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
KISS1R:KISS1(68-121) [plasma membrane] (Homo sapiens)
KISS1(68-121) [extracellular region] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
KISS1R:KISS1(68-121) [plasma membrane] (Homo sapiens)
KISS1(68-121) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
KISS1R:KISS1(68-121) [plasma membrane] (Homo sapiens)
KISS1(68-121) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
KISS1R:KISS1(68-121) [plasma membrane] (Homo sapiens)
KISS1(68-121) [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
KISS1(68-121) [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
The Kiss receptor GPR54 binds kisspeptin (Homo sapiens)
KISS1(68-121) [extracellular region] (Homo sapiens)
KISS1R:KISS1(68-121) [plasma membrane] (Homo sapiens)
KISS1(68-121) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15726 KISS1
Gene Names
KISS1, PP5098
Chain
signal peptide:1-19, chain:20-138, peptide:68-121, peptide:108-121, peptide:109-121, peptide:112-121
Reference Genes
BioGPS Gene:3814 KISS1
COSMIC (genes):KISS1 KISS1
CTD Gene:3814 KISS1
dbSNP Gene:3814 KISS1
ENSEMBL:ENSG00000170498 KISS1
ENSEMBL_homo_sapiens_GENE:ENSG00000170498.10 KISS1
HGNC:6341 KISS1
KEGG Gene (Homo sapiens):3814 KISS1
Monarch:3814 KISS1
NCBI Gene:3814 KISS1
OMIM:603286 KISS1
UCSC:Q15726 KISS1
Reference Transcript
RefSeq:NM_002256.3 KISS1
Other Identifiers
11715454_at
11715455_x_at
1645_at
16698298
205563_PM_at
205563_at
2451919
2451920
2451921
2451922
2451923
2451925
2451926
2451928
3814
7923621
A_23_P124892
GE59168
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0007010
GO:0007186
GO:0007200
GO:0007204
GO:0008285
GO:0016324
GO:0022414
GO:0023052
GO:0031773
GO:0033686
GO:0043025
GO:0043410
GO:0050806
GO:0050886
GO:0060112
GO:0060124
HMNXSV003001994
ILMN_1669404
PH_hs_0005191
TC01003727.hg
U43527_at
g4504872_3p_at
Participates
as an input of
The Kiss receptor GPR54 binds kisspeptin (Homo sapiens)
as a member of
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
as a component of
KISS1R:KISS1(68-121) [plasma membrane] (Homo sapiens)
Inferred To
kiss1 [extracellular region]
(Danio rerio)
Kiss1 [extracellular region]
(Canis familiaris)
Kiss1 [extracellular region]
(Mus musculus)
Kiss1 [extracellular region]
(Rattus norvegicus)
KISS1 [extracellular region]
(Bos taurus)
Cross References
RefSeq
NP_002247.3
OpenTargets
ENSG00000170498
HPA
ENSG00000170498-KISS1
GeneCards
Q15726
Ensembl
ENST00000367194
,
ENSP00000356162
,
ENSG00000170498
PRO
Q15726
Pharos - Targets
Q15726
Orphanet
20822
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UHD9 UBQLN2
1
UBQLN2 [cytosol]
(R-HSA-8866007)
0.556
3
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