The Kiss receptor GPR54 binds kisspeptin

Stable Identifier
R-HSA-388981
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The KiSS1-derived peptide receptor, GPR54 is a galanin-like GPCR (Lee DK et al, 1999) that can bind kisspeptin-54 (metastin), a natural ligand of the receptor (Kotani M et al, 2001). The GPR54 gene appears to be essential for normal puberty and gonadotropin-released hormone physiology (Seminara SB et al, 2003). Metastin is encoded by the KiSS-1 metastasis suppressor gene, a 54-amino acid peptide that suppresses metastases of human melanomas and breast carcinomas without affecting tumorigenicity (Ohtaki T et al, 2001).

Literature References
PubMed ID Title Journal Year
11385580 Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor

Ohtaki, T, Shintani, Y, Honda, S, Matsumoto, H, Hori, A, Kanehashi, K, Terao, Y, Kumano, S, Takatsu, Y, Masuda, Y, Ishibashi, Y, Watanabe, T, Asada, M, Yamada, T, Suenaga, M, Kitada, C, Usuki, S, Kurokawa, T, Onda, H, Nishimura, O, Fujino, M

Nature 2001
11457843 The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54

Kotani, M, Detheux, M, Vandenbogaerde, A, Communi, D, Vanderwinden, JM, Le Poul, E, Brezillon, S, Tyldesley, R, Suarez-Huerta, N, Vandeput, F, Blanpain, C, Schiffmann, SN, Vassart, G, Parmentier, M

J Biol Chem 2001
14573733 The GPR54 gene as a regulator of puberty

Seminara, SB, Messager, S, Chatzidaki, EE, Thresher, RR, Acierno JS, Jr, Shagoury, JK, Bo-Abbas, Y, Kuohung, W, Schwinof, KM, Hendrick, AG, Zahn, D, Dixon, J, Kaiser, UB, Slaugenhaupt, SA, Gusella, JF, O'Rahilly, S, Carlton, MB, Crowley WF, Jr, Aparicio, SA, Colledge, WH

N Engl J Med 2003
10100623 Discovery of a receptor related to the galanin receptors

Lee, DK, Nguyen, T, O'Neill, GP, Cheng, R, Liu, Y, Howard, AD, Coulombe, N, Tan, CP, Tang-Nguyen, AT, George, SR, O'Dowd, BF

FEBS Lett 1999
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