Reactome | NPY [extracellular region]

NPY [extracellular region]

Stable Identifier

R-HSA-388906

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Neuropeptide Y, NPY(29-64), RecName: Full=Neuropeptide Y; Contains: RecName: Full=Neuropeptide Y; AltName: Full=Neuropeptide tyrosine; Short=NPY; Contains: RecName: Full=C-flanking peptide of NPY; Short=CPON; Flags: Precursor;
GN Name=NPY;
OS Homo sapiens, NPY_HUMAN

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        NPY receptor ligands [extracellular region] (Homo sapiens)
        
        NPY [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        NPY receptor ligands [extracellular region] (Homo sapiens)
        
        NPY [extracellular region] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        NPY receptor ligands [extracellular region] (Homo sapiens)
        
        NPY [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        NPY receptor ligands [extracellular region] (Homo sapiens)
        
        NPY [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        NPY receptor ligands [extracellular region] (Homo sapiens)
        
        NPY [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        NPY receptor ligands [extracellular region] (Homo sapiens)
        
        NPY [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Homo sapiens)
        
        NPY receptor ligands [extracellular region] (Homo sapiens)
        
        NPY [extracellular region] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        NPY receptor ligands [extracellular region] (Homo sapiens)
        
        NPY [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P01303 NPY

Gene Names

NPY

Chain

signal peptide:1-28, peptide:29-64, peptide:68-97

Reference Genes

BioGPS Gene:4852 NPY

COSMIC (genes):NPY NPY

CTD Gene:4852 NPY

dbSNP Gene:4852 NPY

ENSEMBL:ENSG00000122585 NPY

HGNC:7955 NPY

KEGG Gene (Homo sapiens):4852 NPY

Monarch:4852 NPY

NCBI Gene:4852 NPY

OMIM:162640 NPY

UCSC:P01303 NPY

Reference Transcript

RefSeq:NM_000905.3 NPY

Other Identifiers

0000540072

11757560_a_at

17044372

206001_at

2993137

2993139

2993140

2993141

2993142

2993146

2993152

2993153

38604_at

4852

8131919

A_23_P256470

GE57534

GO:0001664

GO:0003013

GO:0003674

GO:0004930

GO:0005102

GO:0005179

GO:0005184

GO:0005246

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005794

GO:0007165

GO:0007186

GO:0007187

GO:0007218

GO:0007267

GO:0007268

GO:0007631

GO:0008150

GO:0008217

GO:0008343

GO:0021954

GO:0021987

GO:0030154

GO:0031175

GO:0031410

GO:0032100

GO:0043226

GO:0045202

GO:0048856

GO:0060575

GO:0098992

ILMN_1731062

K01911_at

PH_hs_0000245

TC07000153.hg

g4505448_3p_at

Participant Of

output

NPY gene expression is stimulated by FOXO1

hasMember

NPY receptor ligands [extracellular region]

Inferred To

NPY [extracellular region] (Canis familiaris)

NPY [extracellular region] (Gallus gallus)

NPY [extracellular region] (Sus scrofa)

NPY2 [extracellular region] (Xenopus tropicalis)

Homologues of NPY [extracellular region] (Xenopus tropicalis)

npy [extracellular region] (Danio rerio)

npy [extracellular region] (Xenopus tropicalis)

Npy [extracellular region] (Mus musculus)

Npy [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_000896.1

OpenTargets

ENSG00000122585

GeneCards

P01303

HPA

ENSG00000122585-NPY

Ensembl

ENSP00000385282, ENSP00000384364, ENST00000405982, ENSP00000242152, ENST00000242152, ENST00000407573, ENSG00000122585

PRO

P01303

Orphanet

25739

PDB

1QFA, 1RON

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:F1D8P7 F1D8P7			0.556	3
UniProt:Q9UHD9 UBQLN2	1	UBQLN2 [cytosol] (R-HSA-8866007)	0.556	3

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