NPY gene expression is stimulated by FOXO1

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R-HSA-9622981
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Reaction [omitted]
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Homo sapiens
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FOXO1 directly stimulates transcription of the NPY gene, encoding neuropeptide-Y, in hypothalamic orexigenic neurons. NPY stimulates food intake and weight gain. Insulin and leptin, through PI3K/AKT signaling, inhibit FOXO1-mediated upregulation of NPY expression (Kim et al. 2006). NPY may act through a positive feedback loop to increase the transcriptional activity of FOXO1 through the PKA/CREB pathway (Hong et al. 2012).

Literature References
PubMed ID Title Journal Year
16783365 Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis

Kim, MS, Pak, YK, Jang, PG, Namkoong, C, Choi, YS, Won, JC, Kim, KS, Kim, SW, Kim, HS, Park, JY, Kim, YB, Lee, KU

Nat. Neurosci. 2006
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