NPY gene expression is stimulated by FOXO1

Stable Identifier
R-HSA-9622981
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, extracellular region
ReviewStatus
5/5
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NPY gene expression is stimulated by FOXO1
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FOXO1 directly stimulates transcription of the NPY gene, encoding neuropeptide-Y, in hypothalamic orexigenic neurons. NPY stimulates food intake and weight gain. Insulin and leptin, through PI3K/AKT signaling, inhibit FOXO1-mediated upregulation of NPY expression (Kim et al. 2006). NPY may act through a positive feedback loop to increase the transcriptional activity of FOXO1 through the PKA/CREB pathway (Hong et al. 2012).
Literature References
PubMed ID Title Journal Year
16783365 Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis

Kim, MS, Pak, YK, Jang, PG, Namkoong, C, Choi, YS, Won, JC, Kim, KS, Kim, SW, Kim, HS, Park, JY, Kim, YB, Lee, KU

Nat. Neurosci. 2006
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
FOXO1:NPY gene [nucleoplasm] (Homo sapiens)
Active Unit
FOXO1 [nucleoplasm]
Authored
Orlic-Milacic, M  (2018-10-11)
Reviewed
Donlon, T  (2018-10-17)
Bertaggia, E  (2018-10-26)
Created
Orlic-Milacic, M  (2018-10-02)
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