Reactome | AVP(20-28) binds AVPR1A,B

AVP(20-28) binds AVPR1A,B

Stable Identifier

R-HSA-388468

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Vasopressin-like receptors (Homo sapiens)
        
        AVP(20-28) binds AVPR1A,B (Homo sapiens)

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In humans there are three main arginine vasopressin receptors; AVPR1A, 1B and 2. AVPR1A (Thibonnier et al. 1994) and AVPR1B (Sugimoto et al. 1994) act as receptors for the signal peptide Arg-vasopressin (AVP(20-28)), a cleaved peptide from the precursor AVP protein (Mohr et al. 1985, Sausville et al. 1985) and are expressed mainly in the brain. The 1A and 1B forms use G protein alpha q/11 subunits as their second messenger system.

Literature References

PubMed ID	Title	Journal	Year
7929452	Molecular cloning and functional expression of a cDNA encoding the human V1b vasopressin receptor Sugimoto, T, Saito, M, Mochizuki, S, Watanabe, Y, Hashimoto, S, Kawashima, H	J Biol Chem	1994
8106369	Molecular cloning, sequencing, and functional expression of a cDNA encoding the human V1a vasopressin receptor Thibonnier, M, Auzan, C, Madhun, Z, Wilkins, P, Berti-Mattera, L, Clauser, E	J Biol Chem	1994
2991279	The human vasopressin gene is linked to the oxytocin gene and is selectively expressed in a cultured lung cancer cell line Sausville, E, Carney, D, Battey, J	J Biol Chem	1985
4065330	Expression of the vasopressin and oxytocin genes in human hypothalami Mohr, E, Hillers, M, Ivell, R, Haulica, ID, Richter, D	FEBS Lett	1985