AVP(20-28) binds AVPR1A,B

Stable Identifier
R-HSA-388468
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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In humans there are three main arginine vasopressin receptors; AVPR1A, 1B and 2. AVPR1A (Thibonnier et al. 1994) and AVPR1B (Sugimoto et al. 1994) act as receptors for the signal peptide Arg-vasopressin (AVP(20-28)), a cleaved peptide from the precursor AVP protein (Mohr et al. 1985, Sausville et al. 1985) and are expressed mainly in the brain. The 1A and 1B forms use G protein alpha q/11 subunits as their second messenger system.

Literature References
PubMed ID Title Journal Year
8106369 Molecular cloning, sequencing, and functional expression of a cDNA encoding the human V1a vasopressin receptor

Thibonnier, M, Auzan, C, Madhun, Z, Wilkins, P, Berti-Mattera, L, Clauser, E

J Biol Chem 1994
7929452 Molecular cloning and functional expression of a cDNA encoding the human V1b vasopressin receptor

Sugimoto, T, Saito, M, Mochizuki, S, Watanabe, Y, Hashimoto, S, Kawashima, H

J Biol Chem 1994
2991279 The human vasopressin gene is linked to the oxytocin gene and is selectively expressed in a cultured lung cancer cell line

Sausville, E, Carney, D, Battey, J

J Biol Chem 1985
4065330 Expression of the vasopressin and oxytocin genes in human hypothalami

Mohr, E, Hillers, M, Ivell, R, Haulica, ID, Richter, D

FEBS Lett 1985
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