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p-Y705-STAT3 dimer [nucleoplasm]
Stable Identifier
R-HSA-1112525
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
2x(p-Y705-STAT3)
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Senescence-Associated Secretory Phenotype (SASP) (Homo sapiens)
Activated STAT3 positively regulates CEBPB transcription (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Transcriptional regulation of granulopoiesis (Homo sapiens)
CEBPB and phospho-STAT3 bind the promoter of the MYC gene (Homo sapiens)
MYC gene:phospho-STAT3:CEBPB [nucleoplasm] (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
CEBPB gene transcription is enhanced by phospho-CREB1 and phospho-STAT3 (Homo sapiens)
CEBPB gene:p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
MYC gene expression is enhanced by E2F1, STAT3, and CEBPB and repressed by CEBPA (Homo sapiens)
MYC gene:phospho-STAT3:CEBPB [nucleoplasm] (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
Phospho-STAT3 binds the promoter of the CEBPB gene (Homo sapiens)
CEBPB gene:p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
Transcriptional regulation of pluripotent stem cells (Homo sapiens)
Expression of SALL4 (Homo sapiens)
POU5F1:STAT3:SALL4 gene [nucleoplasm] (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), STAT3 bind the SALL4 promoter (Homo sapiens)
POU5F1:STAT3:SALL4 gene [nucleoplasm] (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by CSF3 (G-CSF) (Homo sapiens)
Inactivation of CSF3 (G-CSF) signaling (Homo sapiens)
p-Y-STAT1,3,5 dimer binds SOCS1 gene (Homo sapiens)
p-Y-STAT1,3,5 dimer [nucleoplasm] (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y-STAT1,3,5 dimer:SOCS1 gene [nucleoplasm] (Homo sapiens)
p-Y-STAT1,3,5 dimer [nucleoplasm] (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y-STAT1,3,5 dimer binds SOCS3 gene (Homo sapiens)
p-Y-STAT1,3,5 dimer [nucleoplasm] (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y-STAT1,3,5 dimer:SOCS3 gene [nucleoplasm] (Homo sapiens)
p-Y-STAT1,3,5 dimer [nucleoplasm] (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y-STAT1,3,5 dimer enhances expression of SOCS1 (Homo sapiens)
p-Y-STAT1,3,5 dimer:SOCS1 gene [nucleoplasm] (Homo sapiens)
p-Y-STAT1,3,5 dimer [nucleoplasm] (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y-STAT1,3,5 dimer enhances expression of SOCS3 (Homo sapiens)
p-Y-STAT1,3,5 dimer:SOCS3 gene [nucleoplasm] (Homo sapiens)
p-Y-STAT1,3,5 dimer [nucleoplasm] (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y-STAT1,3,5 dimer translocates from the cytosol to the nucleoplasm (Homo sapiens)
p-Y-STAT1,3,5 dimer [nucleoplasm] (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-10 signaling (Homo sapiens)
Expression of PTGS2 (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
Interleukin-20 family signaling (Homo sapiens)
p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of BCL2, BCL2L1 (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
Expression of FASLG (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
Expression of HSP90B1 (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
Expression of NDN,TP53 (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
Expression of PTGS2 (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
Expression of STAT3-upregulated cytosolic proteins (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
Expression of STAT3-upregulated extracellular proteins (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
Expression of STAT3-upregulated nuclear proteins (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
Expression of STAT3-upregulated plasma membrane proteins (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y-STATs translocate to nucleus (Homo sapiens)
p-Y701-STAT1 dimer,p-Y705-STAT3 dimer,p-Y641-STAT6 dimer [nucleoplasm] (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Homo sapiens)
p-Y705-STAT3 dimer, p-Y641-STAT6 dimer [nucleoplasm] (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
Interleukin-6 family signaling (Homo sapiens)
Interleukin-6 signaling (Homo sapiens)
STAT1 and STAT3 dimers translocate to the nucleus (Homo sapiens)
STAT1/3 homo and heterodimers [nucleoplasm] (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members (Homo sapiens)
Expression of BCL2, BCL2L1 (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Leptin (Homo sapiens)
Phosphorylated STAT3 Dimer Translocates to the Nucleus (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PTK6 (Homo sapiens)
PTK6 Activates STAT3 (Homo sapiens)
Phosphorylated STAT3 Dimer Translocates to the Nucleus (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
STAT3 binds SOCS3 promoter (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705-STAT3 dimer:SOCS3 Gene [nucleoplasm] (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
STAT3 stimulates SOCS3 expression (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705-STAT3 dimer:SOCS3 Gene [nucleoplasm] (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by MET (Homo sapiens)
MET activates STAT3 (Homo sapiens)
Phosphorylated STAT3 Dimer Translocates to the Nucleus (Homo sapiens)
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
Participants
components
x 2
p-Y705-STAT3 [nucleoplasm]
(Homo sapiens)
Participates
as a member of
p-Y701-STAT1 dimer,p-Y705-STAT3 dimer,p-Y641-STAT6 dimer [nucleoplasm] (Homo sapiens)
p-Y-STAT1,3,5 dimer [nucleoplasm] (Homo sapiens)
STAT1/3 homo and heterodimers [nucleoplasm] (Homo sapiens)
p-Y705-STAT3 dimer, p-Y641-STAT6 dimer [nucleoplasm] (Homo sapiens)
as an output of
p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Homo sapiens)
Phosphorylated STAT3 Dimer Translocates to the Nucleus (Homo sapiens)
as an input of
POU5F1 (OCT4), STAT3 bind the SALL4 promoter (Homo sapiens)
Phospho-STAT3 binds the promoter of the CEBPB gene (Homo sapiens)
CEBPB and phospho-STAT3 bind the promoter of the MYC gene (Homo sapiens)
STAT3 binds SOCS3 promoter (Homo sapiens)
as a component of
POU5F1:STAT3:SALL4 gene [nucleoplasm] (Homo sapiens)
CEBPB gene:p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
MYC gene:phospho-STAT3:CEBPB [nucleoplasm] (Homo sapiens)
p-Y705-STAT3 dimer:SOCS3 Gene [nucleoplasm] (Homo sapiens)
This entity regulates
Negatively
Expression of NDN,TP53
(Homo sapiens)
Expression of FASLG
(Homo sapiens)
Positively
Expression of STAT3-upregulated cytosolic proteins
(Homo sapiens)
Expression of STAT3-upregulated nuclear proteins
(Homo sapiens)
Expression of HSP90B1
(Homo sapiens)
Expression of STAT3-upregulated plasma membrane proteins
(Homo sapiens)
Expression of STAT3-upregulated extracellular proteins
(Homo sapiens)
Expression of PTGS2
(Homo sapiens)
Expression of BCL2, BCL2L1
(Homo sapiens)
Activated STAT3 positively regulates CEBPB transcription
(Homo sapiens)
Inferred To
p-Y705-STAT3 dimer [nucleoplasm]
(Bos taurus)
p-Y705-STAT3 dimer [nucleoplasm]
(Caenorhabditis elegans)
p-Y705-STAT3 dimer [nucleoplasm]
(Canis familiaris)
p-Y705-STAT3 dimer [nucleoplasm]
(Dictyostelium discoideum)
p-Y705-STAT3 dimer [nucleoplasm]
(Drosophila melanogaster)
p-Y705-STAT3 dimer [nucleoplasm]
(Gallus gallus)
p-Y705-STAT3 dimer [nucleoplasm]
(Mus musculus)
p-Y705-STAT3 dimer [nucleoplasm]
(Rattus norvegicus)
p-Y705-STAT3 dimer [nucleoplasm]
(Sus scrofa)
p-Y705-STAT3 dimer [nucleoplasm]
(Xenopus tropicalis)
Cross References
ComplexPortal
CPX-6049
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