Reactome | Tachykinin receptor 2 (NK2) binds to nuerokinin A

Tachykinin receptor 2 (NK2) binds to nuerokinin A

Stable Identifier

R-HSA-383363

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Tachykinin receptors bind tachykinins (Homo sapiens)
        
        Tachykinin receptor 2 (NK2) binds to nuerokinin A (Homo sapiens)

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Tachykinin receptor 2 (NK2) binds to nuerokinin A

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Neurokinin A (substance K) (Gerard NP et al, 1990) is a peptide neurotransmitter of the tachykinin family which can act as a mediator in human airway and gastrointestinal tissues. Neurokinin A acts via the substance K receptor (NK-2 receptor) (Harmar AJ et al, 1986), believed to be localized on smooth muscle cells and pharmacologically coupled to a GTP-binding protein.

Literature References

PubMed ID	Title	Journal	Year
2173708	The human neurokinin A (substance K) receptor. Molecular cloning of the gene, chromosome localization, and isolation of cDNA from tracheal and gastric tissues Gerard, NP, Eddy, RL, Shows, TB, Gerard, C	J Biol Chem	1990
3770210	cDNA sequence of human beta-preprotachykinin, the common precursor to substance P and neurokinin A Harmar, AJ, Armstrong, A, Pascall, JC, Chapman, K, Rosie, R, Curtis, A, Going, J, Edwards, CR, Fink, G	FEBS Lett	1986