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TACR2 [plasma membrane]
Stable Identifier
R-HSA-380135
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Substance K receptor, NK2R_HUMAN, NK2 receptor
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
TACR2:TAC1(98-107) [plasma membrane] (Homo sapiens)
TACR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
TACR2:TAC1(98-107) [plasma membrane] (Homo sapiens)
TACR2 [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
TACR2:TAC1(98-107) [plasma membrane] (Homo sapiens)
TACR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
TACR2:TAC1(98-107) [plasma membrane] (Homo sapiens)
TACR2 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
TACR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
TACR2:TAC1(98-107) [plasma membrane] (Homo sapiens)
TACR2 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Tachykinin receptors bind tachykinins (Homo sapiens)
Tachykinin receptor 2 (NK2) binds to nuerokinin A (Homo sapiens)
TACR2 [plasma membrane] (Homo sapiens)
TACR2:TAC1(98-107) [plasma membrane] (Homo sapiens)
TACR2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P21452 TACR2
Gene Names
TACR2, NK2R, NKNAR, TAC2R
Chain
chain:1-398
Reference Genes
BioGPS Gene:6865 TACR2
COSMIC (genes):TACR2 TACR2
CTD Gene:6865 TACR2
dbSNP Gene:6865 TACR2
ENSEMBL:ENSG00000075073 TACR2
HGNC:11527 TACR2
KEGG:hsa:6865 TACR2
Monarch:6865 TACR2
NCBI Gene:6865 TACR2
OMIM:162321 TACR2
UCSC:P21452 TACR2
Reference Transcript
RefSeq:NM_001057.2 TACR2
Other Identifiers
11733318_a_at
16715064
214348_PM_at
214348_at
3292948
3292949
3292950
3292951
3292952
3292953
3292954
3292955
3292957
3292958
3292959
3292960
3292962
3292963
3292964
3292965
3292966
3292967
3292968
35404_at
6865
7934074
A_23_P24135
GE80978
GO:0003012
GO:0003013
GO:0004930
GO:0004995
GO:0005515
GO:0005886
GO:0005929
GO:0006936
GO:0007165
GO:0007186
GO:0007217
GO:0014057
GO:0014827
GO:0016020
GO:0016497
GO:0033685
GO:0035106
GO:0036126
GO:0043117
GO:0043226
GO:0043270
GO:0045987
GO:0050877
GO:0051602
GO:0060089
GO:0061827
GO:0070459
GO:0070472
GO:0070474
GO:0097225
GO:1902093
HMNXSV003003308
Hs.161305.0.S1_3p_at
ILMN_1753006
M60284_s_at
PH_hs_0009798
TC10001356.hg
Participates
as an input of
Tachykinin receptor 2 (NK2) binds to nuerokinin A (Homo sapiens)
as a member of
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
as a component of
TACR2:TAC1(98-107) [plasma membrane] (Homo sapiens)
Inferred To
TACR2 [plasma membrane]
(Bos taurus)
TACR2 [plasma membrane]
(Canis familiaris)
TACR2 [plasma membrane]
(Gallus gallus)
TACR2 [plasma membrane]
(Sus scrofa)
tkr-1 [plasma membrane]
(Caenorhabditis elegans)
Tacr2 [plasma membrane]
(Mus musculus)
Tacr2 [plasma membrane]
(Rattus norvegicus)
tacr2 [plasma membrane]
(Danio rerio)
Cross References
RefSeq
NP_001048.2
ZINC - World Drugs
NK2R_HUMAN
Guide to Pharmacology - Targets
361
ENSEMBL
ENST00000373306
,
ENSP00000362403
OpenTargets
ENSG00000075073
ZINC - FDA approved
NK2R_HUMAN
ZINC - Substances
NK2R_HUMAN
ZINC - Biogenic
NK2R_HUMAN
ZINC target
P21452
PRO
P21452
GlyGen
P21452
PDB
7XWO
ZINC - Investigational
NK2R_HUMAN
ZINC - Metabolites
NK2R_HUMAN
HPA
ENSG00000075073-TACR2
Pharos - Targets
P21452
ZINC - Predictions - Purchasable
NK2R_HUMAN
HMDB Protein
HMDBP07843
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