Tachykinin receptors bind tachykinins

Stable Identifier
R-HSA-380095
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

Tachykinin peptides are one of the largest family of neuropeptides, so named due to their ability to rapidly induce contraction of gut tissue. Tachykinins excite neurons, elicit behavioural responses, are potent vasodilators and contract many smooth muscles. The tachykinin family is characterized by a common C-terminal sequence, Phe-X-Gly-Leu-Met-NH2 (where X can be either an aromatic or an aliphatic amino acid) and are ten to twelve residues long.

These peptides elicit their effects via the tachykinin receptors, of which there are three types in humans (NK1,2 and 3). There are two human tachykinin peptide genes in humans, TAC1 and TAC3. TAC1 encodes substance P and substance K while TAC3 encodes neurokinin B.

Antagonists of these receptors are promising candidates for classes of antidepressants, anxiolytics and antipsychotics.

Literature References
PubMed ID Title Journal Year
15224188 Hemokinins and endokinins

Page, NM

Cell Mol Life Sci 2004
16918325 Overview of the primary structure, tissue-distribution, and functions of tachykinins and their receptors

Satake, H, Kawada, T

Curr Drug Targets 2006
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created
Cite Us!