Reactome | GLP1R:GLP1 activates G(s)

GLP1R:GLP1 activates G(s)

Stable Identifier

R-HSA-381706

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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GLP-1R that has bound GLP-1 activates the alpha subunit of the heterotrimeric G-protein G(s) by protein-protein interaction between intracellular loop 3 of GLP-1R and G(s). The activation causes exchange of GDP for GTP by the alpha subunit of G(s).

Literature References

PubMed ID	Title	Journal	Year
15569269	Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential Gromada, J, Brock, B, Schmitz, O, Rorsman, P	Basic Clin Pharmacol Toxicol	2004
8405712	Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor Thorens, B, Porret, A, Buhler, L, Deng, SP, Morel, P, Widmann, C	Diabetes	1993
17900700	G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes Winzell, MS, Ahren, B	Pharmacol Ther	2007
17306374	Mechanisms of action of glucagon-like peptide 1 in the pancreas Doyle, ME, Egan, JM	Pharmacol Ther	2007
19859570	Functional Characterization of N-Terminally GFP-Tagged GLP-1 Receptor Bavec, A, Licar, A	J Biomed Biotechnol	2009