GLP-1R that has bound GLP-1 activates the alpha subunit of the heterotrimeric G-protein G(s) by protein-protein interaction between intracellular loop 3 of GLP-1R and G(s). The activation causes exchange of GDP for GTP by the alpha subunit of G(s).
Thorens, B, Porret, A, Buhler, L, Deng, SP, Morel, P, Widmann, C
Gromada, J, Brock, B, Schmitz, O, Rorsman, P
Winzell, MS, Ahren, B
Doyle, ME, Egan, JM
Bavec, A, Licar, A
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