GLP-1R:GLP-1 activates G(s)

Stable Identifier
R-HSA-381706
Type
Reaction
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Locations in the PathwayBrowser
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Summation

GLP-1R that has bound GLP-1 activates the alpha subunit of the heterotrimeric G-protein G(s) by protein-protein interaction between intracellular loop 3 of GLP-1R and G(s). The activation causes exchange of GDP for GTP by the alpha subunit of G(s).

Literature References
PubMed ID Title Journal Year
8405712 Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor

Thorens, B, Porret, A, Buhler, L, Deng, SP, Morel, P, Widmann, C

Diabetes 1993
15569269 Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential

Gromada, J, Brock, B, Schmitz, O, Rorsman, P

Basic Clin Pharmacol Toxicol 2004
17900700 G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes

Winzell, MS, Ahren, B

Pharmacol Ther 2007
17306374 Mechanisms of action of glucagon-like peptide 1 in the pancreas

Doyle, ME, Egan, JM

Pharmacol Ther 2007
19859570 Functional Characterization of N-Terminally GFP-Tagged GLP-1 Receptor

Bavec, A, Licar, A

J Biomed Biotechnol 2009
Participants
Input
Output
Participant Of
hasEvent
Inferred From
Activation of G(s) by the Glucagon-like peptide-1 receptor (Glp1r, rat) (Rattus norvegicus)
Authored
May, B  (2009-05-28)
Reviewed
Gillespie, ME  (2009-06-02)
Calamita, G  (2010-07-15)