GLP1R:GLP1 activates G(s)

Stable Identifier
Homo sapiens
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GLP-1R that has bound GLP-1 activates the alpha subunit of the heterotrimeric G-protein G(s) by protein-protein interaction between intracellular loop 3 of GLP-1R and G(s). The activation causes exchange of GDP for GTP by the alpha subunit of G(s).

Literature References
PubMed ID Title Journal Year
15569269 Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential

Brock, B, Gromada, J, Rorsman, P, Schmitz, O

Basic Clin Pharmacol Toxicol 2004
8405712 Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor

Morel, P, Widmann, C, Thorens, B, Porret, A, Buhler, L, Deng, SP

Diabetes 1993
17900700 G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes

Ahren, B, Winzell, MS

Pharmacol Ther 2007
17306374 Mechanisms of action of glucagon-like peptide 1 in the pancreas

Egan, JM, Doyle, ME

Pharmacol Ther 2007
19859570 Functional Characterization of N-Terminally GFP-Tagged GLP-1 Receptor

Bavec, A, Licar, A

J Biomed Biotechnol 2009
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