Reactome | MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)

MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)

Stable Identifier

R-HSA-381135

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane

ReviewStatus

5/5

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Once in the Golgi, ATF6-alpha undergoes two sequential proteolytic cleavages. S1P catalyzes the first of these, probably cleaving the ATF6-alpha polypeptide between residues 418 and 419 based on homology with known S1P cleavage sites in other proteins.

Literature References

PubMed ID	Title	Journal	Year
10564271	Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress Haze, K, Yoshida, H, Yanagi, H, Yura, T, Mori, K	Mol Biol Cell	1999
15299016	Dependence of site-2 protease cleavage of ATF6 on prior site-1 protease digestion is determined by the size of the luminal domain of ATF6 Shen, J, Prywes, R	J Biol Chem	2004
11163209	ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs Ye, J, Rawson, RB, Komuro, R, Chen, X, Davé, UP, Prywes, R, Brown, MS, Goldstein, JL	Mol Cell	2000