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ATF6 [Golgi membrane]
Stable Identifier
R-HSA-381000
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi membrane
Synonyms
ATF6-alpha
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Unfolded Protein Response (UPR) (Homo sapiens)
ATF6 (ATF6-alpha) activates chaperones (Homo sapiens)
ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Homo sapiens)
ATF6 [Golgi membrane] (Homo sapiens)
MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Homo sapiens)
ATF6 [Golgi membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P18850 ATF6
Gene Names
ATF6
Chain
chain:1-670, chain:1-
Reference Genes
BioGPS Gene:22926 ATF6
COSMIC (genes):ATF6 ATF6
CTD Gene:22926 ATF6
dbSNP Gene:22926 ATF6
ENSEMBL:ENSG00000118217 ATF6
ENSEMBL_homo_sapiens_GENE:ENSG00000118217.7 ATF6
HGNC:791 ATF6
KEGG Gene (Homo sapiens):22926 ATF6
Monarch:22926 ATF6
NCBI Gene:22926 ATF6
OMIM:605537 ATF6
UCSC:P18850 ATF6
Reference Transcript
RefSeq:NM_007348.3 ATF6
Other Identifiers
11740461_a_at
11745173_a_at
11745174_a_at
16672988
203952_3p_at
203952_PM_at
203952_at
217550_PM_at
217550_at
226941_PM_at
226941_at
22926
231927_PM_at
231927_at
2363920
2363921
2363922
2363923
2363925
2363928
2363929
2363931
2363933
2363934
2363938
2363940
2363951
2363955
2363956
2363957
2363960
2363961
2363966
2363978
2363979
2363980
2363981
2363982
2363983
2363984
2363985
2363986
2363987
2364002
338_at
52002_at
7906819
83877_at
AF005887_at
A_14_P112649
A_14_P139281
A_23_P62907
A_24_P453259
GE62141
GE86196
GE86197
GO:0000139
GO:0000785
GO:0000976
GO:0000977
GO:0000978
GO:0000981
GO:0001228
GO:0001654
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005635
GO:0005654
GO:0005694
GO:0005783
GO:0005789
GO:0005794
GO:0005829
GO:0006351
GO:0006355
GO:0006357
GO:0006457
GO:0006914
GO:0006986
GO:0007165
GO:0007601
GO:0010508
GO:0012501
GO:0016020
GO:0019899
GO:0023052
GO:0030163
GO:0030968
GO:0034976
GO:0036500
GO:0036503
GO:0042802
GO:0043065
GO:0043226
GO:0043565
GO:0045944
GO:0046982
GO:0048856
GO:0050877
GO:0090575
GO:0140110
GO:1903893
GO:1990837
HMNXSV003025320
Hs.158849.0.S1_3p_at
Hs.252497.0.A1_3p_at
Hs.40328.0.A1_3p_at
ILMN_1703471
PH_hs_0025264
TC01001414.hg
TC01004799.hg
g6671584_3p_at
g6671584_3p_s_at
g6671584_3p_x_at
Participates
as an input of
MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Homo sapiens)
as an output of
ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Homo sapiens)
Other forms of this molecule
ATF6 [endoplasmic reticulum membrane]
ATF6(1-419) [Golgi membrane]
ATF6(1-380) [cytosol]
ATF6(380-419) [Golgi membrane]
ATF6(420-670) [Golgi membrane]
ATF6(1-380) [nucleoplasm]
Inferred To
ATF6 [Golgi membrane]
(Bos taurus)
ATF6 [Golgi membrane]
(Canis familiaris)
ATF6 [Golgi membrane]
(Gallus gallus)
ATF6 [Golgi membrane]
(Sus scrofa)
Homologues of ATF6 [Golgi membrane]
(Dictyostelium discoideum)
bzpC [Golgi membrane]
(Dictyostelium discoideum)
Atf6 [Golgi membrane]
(Drosophila melanogaster)
Atf6 [Golgi membrane]
(Mus musculus)
Atf6 [Golgi membrane]
(Rattus norvegicus)
atf6 [Golgi membrane]
(Xenopus tropicalis)
atf-6 [Golgi membrane]
(Caenorhabditis elegans)
bzpL [Golgi membrane]
(Dictyostelium discoideum)
Modified Residues
Name
glycosylated residue at 472
Coordinate
472
PsiMod Name
glycosylated residue
PsiMod Definition
A protein modification that effectively replaces a hydrogen atom with an carbohydrate-like group through a glycosidic bond.
Name
glycosylated residue at 584
Coordinate
584
PsiMod Name
glycosylated residue
PsiMod Definition
A protein modification that effectively replaces a hydrogen atom with an carbohydrate-like group through a glycosidic bond.
Name
glycosylated residue at 643
Coordinate
643
PsiMod Name
glycosylated residue
PsiMod Definition
A protein modification that effectively replaces a hydrogen atom with an carbohydrate-like group through a glycosidic bond.
Cross References
RefSeq
NP_031374.2
OpenTargets
ENSG00000118217
HPA
ENSG00000118217-ATF6
GeneCards
P18850
Ensembl
ENST00000681738
,
ENSP00000505025
,
ENST00000681801
,
ENST00000367942
,
ENSG00000118217
,
ENSP00000505998
,
ENSP00000356919
PRO
P18850
Pharos - Targets
P18850
Orphanet
23342
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P18850 ATF6
7
ATF6 [endoplasmic reticulum membrane]
(R-HSA-381222)
ATF6 [Golgi membrane]
(R-HSA-381000)
ATF6(1-419) [Golgi membrane]
(R-HSA-420815)
ATF6(1-380) [cytosol]
(R-HSA-381075)
ATF6(380-419) [Golgi membrane]
(R-HSA-420817)
ATF6(420-670) [Golgi membrane]
(R-HSA-420814)
ATF6(1-380) [nucleoplasm]
(R-HSA-381211)
0.792
6
UniProt:P17861 XBP1
0.623
4
UniProt:P33151 CDH5
2
p-S665-VE-cadherin [plasma membrane]
(R-HSA-5357435)
VE-cadherin [plasma membrane]
(R-HSA-418992)
0.527
2
UniProt:Q8NHY2 RFWD2
3
p-S387-RFWD2 [nucleoplasm]
(R-HSA-349450)
RFWD2 [nucleoplasm]
(R-HSA-349454)
p-S387-RFWD2 [cytosol]
(R-HSA-349439)
0.527
2
UniProt:O75596 CLC3A
0.527
2
UniProt:Q96DZ1 ERLEC1
1
ERLEC1 [endoplasmic reticulum quality control compartment]
(R-HSA-5362354)
0.527
2
UniProt:O14764 GBRD
0.527
2
UniProt:Q8N2I9 STK40
0.527
2
UniProt:Q13438 OS9
1
OS9 [endoplasmic reticulum membrane]
(R-HSA-1022132)
0.527
3
UniProt:Q8N6Y1 PCD20
0.527
2
UniProt:Q68CJ9 CREB3L3
10
CREB3L3(1-?) [nucleoplasm]
(R-HSA-6784629)
CREB3L3(1-?) [cytosol]
(R-HSA-6784654)
CREB3L3 [endoplasmic reticulum membrane]
(R-HSA-6784669)
CREB3L3(?-461) [endoplasmic reticulum membrane]
(R-HSA-6784710)
CREB3L3 [Golgi membrane]
(R-HSA-8874144)
CREB3L3(365-461) [Golgi membrane]
(R-HSA-8874130)
CREB3L3(1-364) [Golgi membrane]
(R-HSA-8874158)
CREB3L3(1-323) [cytosol]
(R-HSA-8874214)
CREB3L3(1-323) [nucleoplasm]
(R-HSA-8874217)
CREB3L3(324-364) [Golgi membrane]
(R-HSA-8874183)
0.524
2
UniProt:Q3U182 CRTC2
0.524
2
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