Phosphorylated IRE1 dimer binds ADP

Stable Identifier
R-HSA-381116
Type
Reaction [binding]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol
ReviewStatus
5/5
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Phosphorylated IRE1 dimer binds ADP
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Phosphorylation of the C-terminal region causes a loop in the C-terminus to change position, enabling access to an ADP-binding pocket. Phosphorylated IRE1-alpha dimers bind ADP in preference to ATP.

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Inferred From
Phosphorylated Ire1 Dimer Binds ADP (Saccharomyces cerevisiae)
Authored
May, B  (2009-06-02)
Reviewed
Gillespie, ME  (2008-12-02)
D'Eustachio, P  (2008-12-02)
Matthews, L  (2008-12-02)
Urano, F  (2010-04-30)
Created
May, B  (2008-11-19)
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