Phosphorylated IRE1 dimer binds ADP

Stable Identifier
R-HSA-381116
Type
Reaction
Species
Homo sapiens
Compartment
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Phosphorylation of the C-terminal region causes a loop in the C-terminus to change position, enabling access to an ADP-binding pocket. Phosphorylated IRE1-alpha dimers bind ADP in preference to ATP.

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