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p-S724-IRE1 dimer:ADP [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-381078
Type
Complex
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Unfolded Protein Response (UPR) (Homo sapiens)
IRE1alpha activates chaperones (Homo sapiens)
IRE1alpha hydrolyzes Xbp1 mRNA and Xbp1 mRNA is spliced (Homo sapiens)
p-S724-IRE1 dimer:ADP [endoplasmic reticulum membrane] (Homo sapiens)
Phosphorylated IRE1 dimer binds ADP (Homo sapiens)
p-S724-IRE1 dimer:ADP [endoplasmic reticulum membrane] (Homo sapiens)
General
Phosphorylated IRE1 homodimers preferentially bind ADP (as opposed to ATP) and this binding promotes association of the cytoplasmic C-termini. Crystallographic evidence indicates that unphosphorylated A-loops of IRE1 interfere with nucleotide binding thus trans-autophosphorylation is a prerequisite to nucleotide binding.
Participants
components
x 2
ADP [endoplasmic reticulum membrane]
p-S724-IRE1 dimer [endoplasmic reticulum membrane]
(Homo sapiens)
Participates
as an output of
Phosphorylated IRE1 dimer binds ADP (Homo sapiens)
Inferred From
p-3S,T844-IRE1 dimer:ADP (yeast) [endoplasmic reticulum membrane]
(Saccharomyces cerevisiae)
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