p-S724-IRE1 dimer:ADP [endoplasmic reticulum membrane]

Stable Identifier
R-HSA-381078
Type
Complex
Species
Homo sapiens
Compartment
General

Phosphorylated IRE1 homodimers preferentially bind ADP (as opposed to ATP) and this binding promotes association of the cytoplasmic C-termini. Crystallographic evidence indicates that unphosphorylated A-loops of IRE1 interfere with nucleotide binding thus trans-autophosphorylation is a prerequisite to nucleotide binding.

Participants
Participant Of
Inferred From