Recruitment of CDK11p58 to the centrosomes

Stable Identifier
R-HSA-380455
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Recruitment of CDK11p58 to the centrosomes
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
CDK11p58 is a kinase that is active during mitosis when it associates with centrosomes, and has a crucial role in centrosome maturation and bipolar spindle formation (Petretti et al., 2006). CDK11p58 facilitates microtubule nucleation and is required for the recruitment of Aurora and Plk1 to the centrosome (Petretti et al., 2006).
Literature References
PubMed ID Title Journal Year
16462731 The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation

Glover, DM, Savoian, M, Prigent, C, Montembault, E, Giet, R, Petretti, C

EMBO Rep 2006
Participants
Input
Output
Participates
as an event of
Orthologous Events
Recruitment of CDK11p58 to the centrosomes (Bos taurus)
Recruitment of CDK11p58 to the centrosomes (Canis familiaris)
Recruitment of CDK11p58 to the centrosomes (Gallus gallus)
Recruitment of CDK11p58 to the centrosomes (Mus musculus)
Recruitment of CDK11p58 to the centrosomes (Rattus norvegicus)
Recruitment of CDK11p58 to the centrosomes (Sus scrofa)
Recruitment of CDK11p58 to the centrosomes (Xenopus tropicalis)
Authored
Matthews, L  (2008-11-11)
Reviewed
Merdes, A  (2008-11-17)
Created
Matthews, L  (2008-11-12)
Cite Us!