Reactome | CEP41 [cytosol]

CEP41 [cytosol]

Stable Identifier

R-HSA-380269

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Cep41

Locations in the PathwayBrowser

Expand all

Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Anchoring of the basal body to the plasma membrane (Homo sapiens)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP41 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP41 [cytosol] (Homo sapiens)
    - C2CD3 binds the mother centriole (Homo sapiens)
      - mother centriole [cytosol] (Homo sapiens)
        
        CEP41 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP41 [cytosol] (Homo sapiens)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP41 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP41 [cytosol] (Homo sapiens)
    - CP110 and CEP97 dissociate from the centriole (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP41 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP41 [cytosol] (Homo sapiens)
    - MARK4 binds ODF2 in the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP41 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP41 [cytosol] (Homo sapiens)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP41 [cytosol] (Homo sapiens)
    - Recruitment of transition zone proteins (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP41 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP41 [cytosol] (Homo sapiens)
    - The distal appendage proteins recruit TTBK2 (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP41 [cytosol] (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP41 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BYV8 CEP41

Gene Names

CEP41, TSGA14

Chain

chain:1-373

Reference Genes

BioGPS Gene:95681 CEP41

COSMIC (genes):CEP41 CEP41

CTD Gene:95681 CEP41

dbSNP Gene:95681 CEP41

ENSEMBL:ENSG00000106477 CEP41

HGNC:12370 CEP41

KEGG:hsa:95681 CEP41

Monarch:95681 CEP41

NCBI Gene:95681 CEP41

OMIM:610523 CEP41

UCSC:Q9BYV8 CEP41

Reference Transcript

Other Identifiers

11723436_a_at

11723437_at

11746631_a_at

11751449_x_at

11756460_a_at

11760457_at

1563997_PM_at

1563997_at

17062878

215637_PM_at

215637_at

225484_PM_at

225484_at

225485_PM_at

225485_at

239322_PM_at

239322_at

3072544

3072545

3072547

3072548

3072549

3072550

3072551

3072552

3072553

3072554

3072555

3072556

3072557

3072558

3072559

3072560

3072561

3072562

3072563

3072564

3072565

3072566

3072567

3072568

3072569

3072570

3072571

3072572

3072573

3072574

3072575

3072576

3072577

3072578

3072579

3072580

3072581

3072582

3072583

3072584

3072585

3072587

3072588

3072589

3072590

50110_at

50867_at

55535_at

62390_at

67988_at

70918_at

77902_at

8142930

87227_at

89823_at

95681

A_23_P111413

A_23_P215070

A_24_P155016

GE61779

GE801864

GE85182

GO:0005515

GO:0005737

GO:0005813

GO:0005814

GO:0005815

GO:0005829

GO:0005856

GO:0005929

GO:0015031

GO:0016020

GO:0018095

GO:0030030

GO:0036064

GO:0043226

GO:0044782

GO:0060271

HMNXSV003007907

HMNXSV003020032

Hs.22829.0.A1_3p_at

Hs.27027.0.S1_3p_at

Hs.27027.0.S2_3p_at

Hs.306418.0.S1_3p_at

Hs.306418.0.S1_3p_x_at

Hs2.375896.1.S1_3p_at

ILMN_1797209

ILMN_2223805

PH_hs_0023449

TC07001863.hg

Participates

as a component of

Inferred To

cep41 [cytosol] (Xenopus tropicalis)

CEP41 [cytosol] (Bos taurus)

CEP41 [cytosol] (Canis familiaris)

CEP41 [cytosol] (Gallus gallus)

CEP41 [cytosol] (Sus scrofa)

Cep41 [cytosol] (Mus musculus)

Cep41 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001244089.1, NP_001244088.1, NP_061188.1, NP_001244087.1

ENSEMBL

ENST00000675596, ENSG00000106477, ENST00000489512, ENST00000675962, ENSP00000417815, ENSP00000502478, ENST00000223208, ENSP00000223208, ENSP00000501735

OpenTargets

ENSG00000106477

GeneCards

CEP41

HPA

ENSG00000106477-CEP41

PRO

Q9BYV8

Pharos - Targets

Q9BYV8

GlyGen

Q9BYV8

Orphanet

CEP41

Cite Us!