Reactome | GNAT3 [plasma membrane]

GNAT3 [plasma membrane]

Stable Identifier

R-HSA-380090

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

G-alpha(i) gustducin, GNAT3_HUMAN

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Leishmania parasite growth and survival (Homo sapiens)
        
        Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
        
        ADORA2B mediated anti-inflammatory cytokines production (Homo sapiens)
        
        Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAT3 [plasma membrane] (Homo sapiens)

Hemostasis (Homo sapiens)

- Platelet activation, signaling and aggregation (Homo sapiens)
  - Signal amplification (Homo sapiens)
    - ADP signalling through P2Y purinoceptor 12 (Homo sapiens)
      - Activated P2Y purinoceptor 12 binds G-protein Gi (Homo sapiens)
        
        ADP:P2RY12:G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAT3 [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAT3 [plasma membrane] (Homo sapiens)
      - Dissociation of the P2Y purinoceptor 12:Gi complex (Homo sapiens)
        
        ADP:P2RY12:G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAT3 [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAT3 [plasma membrane] (Homo sapiens)
      - Gi activation by P2Y purinoceptor 12 (Homo sapiens)
        
        ADP:P2RY12:G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAT3 [plasma membrane] (Homo sapiens)
        
        ADP:P2RY12:G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAT3 [plasma membrane] (Homo sapiens)

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - GABA receptor activation (Homo sapiens)
      - GABA B receptor activation (Homo sapiens)
        
        Activation of GABAB receptors (Homo sapiens)
        
        Adenylate cyclase inhibitory pathway (Homo sapiens)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAT3 [plasma membrane] (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAT3 [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Homo sapiens)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAT3 [plasma membrane] (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAT3 [plasma membrane] (Homo sapiens)
        
        Dissociation of the Gi alpha:G olf complex (Homo sapiens)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAT3 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAT3 [plasma membrane] (Homo sapiens)
        
        G alpha (i) inhibits adenylate cyclase (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAT3 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAT3 [plasma membrane] (Homo sapiens)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAT3 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAT3 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:A8MTJ3 GNAT3

Gene Names

GNAT3

Chain

initiator methionine:, chain:2-354

Reference Genes

BioGPS Gene:346562 GNAT3

COSMIC (genes):GNAT3 GNAT3

CTD Gene:346562 GNAT3

dbSNP Gene:346562 GNAT3

ENSEMBL:ENSG00000214415 GNAT3

HGNC:22800 GNAT3

KEGG:hsa:346562 GNAT3

Monarch:346562 GNAT3

NCBI Gene:346562 GNAT3

OMIM:139395 GNAT3

UCSC:A8MTJ3 GNAT3

Reference Transcript

RefSeq:NM_001102386.2 GNAT3

Other Identifiers

11738376_at

17059109

216590_PM_at

216590_at

3058710

3058712

3058713

3058714

3058715

3058716

3058717

3058718

3058719

3058720

3058723

3058725

3058726

346562

A_33_P3409939

GO:0001580

GO:0001664

GO:0001669

GO:0001750

GO:0001917

GO:0003824

GO:0003924

GO:0005525

GO:0005737

GO:0005834

GO:0005886

GO:0005930

GO:0007165

GO:0007186

GO:0007188

GO:0016020

GO:0016324

GO:0016787

GO:0019001

GO:0031410

GO:0031683

GO:0032991

GO:0035094

GO:0043226

GO:0046872

GO:0050877

GO:0050909

GO:0050913

GO:0050916

GO:0050917

HMNXSV003022246

Hs.247768.0.S1_3p_at

ILMN_1706176

PH_hs_0032723

TC07001558.hg

Participates

as a component of

as a member of

G alpha (i) [plasma membrane] (Homo sapiens)

Inferred To

GNAT3 [plasma membrane] (Bos taurus)

GNAT3 [plasma membrane] (Canis familiaris)

GNAT3 [plasma membrane] (Gallus gallus)

GNAT3 [plasma membrane] (Mus musculus)

GNAT3 [plasma membrane] (Sus scrofa)

Gnat3 [plasma membrane] (Rattus norvegicus)

gnat2 [plasma membrane] (Danio rerio)

GNAI3 [plasma membrane] (Dictyostelium discoideum)

GNAI3 [plasma membrane] (Saccharomyces cerevisiae)

GNAI3 [plasma membrane] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_001095856.1

ENSEMBL

ENSP00000381339, ENST00000398291

OpenTargets

ENSG00000214415

HPA

ENSG00000214415-GNAT3

PRO

A8MTJ3

Pharos - Targets

A8MTJ3

GlyGen

A8MTJ3

HMDB Protein

HMDBP07713

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