SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine

Stable Identifier
R-HSA-379426
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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SLC7A6 as a heterodimer with SLC3A2 in the plasma membrane mediates the exchange of arginine for leucine and a sodium ion. The physiological concentrations of arginine and leucine are expected to favor arginine export. By the criterion of Northern blotting, SLC7A6 is expressed in a variety of tissues (Broer et al. 2000).

Literature References
PubMed ID Title Journal Year
10903140 The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux in exchange with glutamine

Broer, A, Wagner, CA, Lang, F, Broer, S

Biochem J 2000
Participants
Participates
Catalyst Activity

amino acid transmembrane transporter activity of SLC7A6:SLC3A2 heterodimer [plasma membrane]

Orthologous Events
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