SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine

Stable Identifier
R-HSA-379426
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine
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SLC7A6 as a heterodimer with SLC3A2 in the plasma membrane mediates the exchange of arginine for leucine and a sodium ion. The physiological concentrations of arginine and leucine are expected to favor arginine export. By the criterion of Northern blotting, SLC7A6 is expressed in a variety of tissues (Broer et al. 2000).
Literature References
PubMed ID Title Journal Year
10903140 The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux in exchange with glutamine

Broer, A, Lang, F, Wagner, CA, Broer, S

Biochem J 2000
Participants
Input
Output
Participates
as an event of
Catalyst Activity

amino acid transmembrane transporter activity of SLC7A6:SLC3A2 heterodimer [plasma membrane]

Physical Entity
SLC7A6:SLC3A2 heterodimer [plasma membrane] (Homo sapiens)
Activity
amino acid transmembrane transporter activity (GO:0015171)
Orthologous Events
SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Bos taurus)
SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Canis familiaris)
SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Danio rerio)
SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Drosophila melanogaster)
SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Mus musculus)
SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Rattus norvegicus)
SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Xenopus tropicalis)
Cross References
Rhea
Authored
D'Eustachio, P  (2008-11-29)
Reviewed
Jassal, B  (2008-11-26)
Created
D'Eustachio, P  (2008-10-29)
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