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About
What is Reactome ?
News
Team
Scientific Advisory Board
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Release Calendar
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Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
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Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
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How do I search ?
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L-Leu [extracellular region]
Stable Identifier
R-ALL-351964
Type
Chemical Compound [SimpleEntity]
Compartment
extracellular region
Synonyms
2-amino-4-methylvaleric acid, L-leucine zwitterion, L-leucine, (2S)-alpha-2-Amino-4-methylvaleric acid, (2S)-alpha-Leucine
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Sus scrofa
Xenopus tropicalis
Expand all
Metabolism (Bos taurus)
Metabolism of amino acids and derivatives (Bos taurus)
Tryptophan catabolism (Bos taurus)
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Bos taurus)
ligands of SLC7A5 [extracellular region]
L-Leu [extracellular region]
Transport of small molecules (Bos taurus)
SLC-mediated transmembrane transport (Bos taurus)
Transport of bile salts and organic acids, metal ions and amine compounds (Bos taurus)
Na+/Cl- dependent neurotransmitter transporters (Bos taurus)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Bos taurus)
SLC6A14 ligands [extracellular region]
L-Leu [extracellular region]
SLC6A15-mediated amino acid uptake (Bos taurus)
ligands of SLC6A15 [extracellular region]
L-Leu [extracellular region]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Bos taurus)
neutral amino acids [extracellular region]
L-Leu [extracellular region]
Transport of inorganic cations/anions and amino acids/oligopeptides (Bos taurus)
Amino acid transport across the plasma membrane (Bos taurus)
SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Bos taurus)
ligands of SLC38A2 [extracellular region]
L-Leu [extracellular region]
SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Bos taurus)
ligands of SLC43A1 and SLC43A2 [extracellular region]
L-Leu [extracellular region]
SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Bos taurus)
ligands of SLC43A1 and SLC43A2 [extracellular region]
L-Leu [extracellular region]
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Bos taurus)
SLC6A14 ligands [extracellular region]
L-Leu [extracellular region]
SLC6A15-mediated amino acid uptake (Bos taurus)
ligands of SLC6A15 [extracellular region]
L-Leu [extracellular region]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Bos taurus)
neutral amino acids [extracellular region]
L-Leu [extracellular region]
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Bos taurus)
ligands of SLC7A5 [extracellular region]
L-Leu [extracellular region]
SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Bos taurus)
L-Leu [extracellular region]
SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Bos taurus)
L-Leu [extracellular region]
SLC7A8-mediated uptake of neutral amino acids (Bos taurus)
ligands of SLC7A8 [extracellular region]
L-Leu [extracellular region]
SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Bos taurus)
L-Leu [extracellular region]
Transport of small molecules (Caenorhabditis elegans)
SLC-mediated transmembrane transport (Caenorhabditis elegans)
Transport of bile salts and organic acids, metal ions and amine compounds (Caenorhabditis elegans)
Na+/Cl- dependent neurotransmitter transporters (Caenorhabditis elegans)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Caenorhabditis elegans)
SLC6A14 ligands [extracellular region]
L-Leu [extracellular region]
Transport of inorganic cations/anions and amino acids/oligopeptides (Caenorhabditis elegans)
Amino acid transport across the plasma membrane (Caenorhabditis elegans)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Caenorhabditis elegans)
SLC6A14 ligands [extracellular region]
L-Leu [extracellular region]
Metabolism (Canis familiaris)
Metabolism of amino acids and derivatives (Canis familiaris)
Tryptophan catabolism (Canis familiaris)
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Canis familiaris)
ligands of SLC7A5 [extracellular region]
L-Leu [extracellular region]
Transport of small molecules (Canis familiaris)
SLC-mediated transmembrane transport (Canis familiaris)
Transport of bile salts and organic acids, metal ions and amine compounds (Canis familiaris)
Na+/Cl- dependent neurotransmitter transporters (Canis familiaris)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Canis familiaris)
SLC6A14 ligands [extracellular region]
L-Leu [extracellular region]
SLC6A15-mediated amino acid uptake (Canis familiaris)
ligands of SLC6A15 [extracellular region]
L-Leu [extracellular region]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Canis familiaris)
neutral amino acids [extracellular region]
L-Leu [extracellular region]
Transport of inorganic cations/anions and amino acids/oligopeptides (Canis familiaris)
Amino acid transport across the plasma membrane (Canis familiaris)
SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Canis familiaris)
ligands of SLC38A2 [extracellular region]
L-Leu [extracellular region]
SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Canis familiaris)
ligands of SLC43A1 and SLC43A2 [extracellular region]
L-Leu [extracellular region]
SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Canis familiaris)
ligands of SLC43A1 and SLC43A2 [extracellular region]
L-Leu [extracellular region]
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Canis familiaris)
SLC6A14 ligands [extracellular region]
L-Leu [extracellular region]
SLC6A15-mediated amino acid uptake (Canis familiaris)
ligands of SLC6A15 [extracellular region]
L-Leu [extracellular region]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Canis familiaris)
neutral amino acids [extracellular region]
L-Leu [extracellular region]
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Canis familiaris)
ligands of SLC7A5 [extracellular region]
L-Leu [extracellular region]
SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Canis familiaris)
L-Leu [extracellular region]
SLC7A8-mediated uptake of neutral amino acids (Canis familiaris)
ligands of SLC7A8 [extracellular region]
L-Leu [extracellular region]
SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Canis familiaris)
L-Leu [extracellular region]
Transport of small molecules (Danio rerio)
SLC-mediated transmembrane transport (Danio rerio)
Transport of bile salts and organic acids, metal ions and amine compounds (Danio rerio)
Na+/Cl- dependent neurotransmitter transporters (Danio rerio)
SLC6A15-mediated amino acid uptake (Danio rerio)
ligands of SLC6A15 [extracellular region]
L-Leu [extracellular region]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Danio rerio)
neutral amino acids [extracellular region]
L-Leu [extracellular region]
Transport of inorganic cations/anions and amino acids/oligopeptides (Danio rerio)
Amino acid transport across the plasma membrane (Danio rerio)
SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Danio rerio)
ligands of SLC38A2 [extracellular region]
L-Leu [extracellular region]
SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Danio rerio)
ligands of SLC43A1 and SLC43A2 [extracellular region]
L-Leu [extracellular region]
SLC6A15-mediated amino acid uptake (Danio rerio)
ligands of SLC6A15 [extracellular region]
L-Leu [extracellular region]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Danio rerio)
neutral amino acids [extracellular region]
L-Leu [extracellular region]
SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Danio rerio)
L-Leu [extracellular region]
SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Danio rerio)
L-Leu [extracellular region]
Metabolism (Drosophila melanogaster)
Metabolism of amino acids and derivatives (Drosophila melanogaster)
Tryptophan catabolism (Drosophila melanogaster)
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Drosophila melanogaster)
ligands of SLC7A5 [extracellular region]
L-Leu [extracellular region]
Transport of small molecules (Drosophila melanogaster)
SLC-mediated transmembrane transport (Drosophila melanogaster)
Transport of bile salts and organic acids, metal ions and amine compounds (Drosophila melanogaster)
Na+/Cl- dependent neurotransmitter transporters (Drosophila melanogaster)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Drosophila melanogaster)
SLC6A14 ligands [extracellular region]
L-Leu [extracellular region]
SLC6A15-mediated amino acid uptake (Drosophila melanogaster)
ligands of SLC6A15 [extracellular region]
L-Leu [extracellular region]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Drosophila melanogaster)
neutral amino acids [extracellular region]
L-Leu [extracellular region]
Transport of inorganic cations/anions and amino acids/oligopeptides (Drosophila melanogaster)
Amino acid transport across the plasma membrane (Drosophila melanogaster)
SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Drosophila melanogaster)
ligands of SLC38A2 [extracellular region]
L-Leu [extracellular region]
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Drosophila melanogaster)
SLC6A14 ligands [extracellular region]
L-Leu [extracellular region]
SLC6A15-mediated amino acid uptake (Drosophila melanogaster)
ligands of SLC6A15 [extracellular region]
L-Leu [extracellular region]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Drosophila melanogaster)
neutral amino acids [extracellular region]
L-Leu [extracellular region]
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Drosophila melanogaster)
ligands of SLC7A5 [extracellular region]
L-Leu [extracellular region]
SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Drosophila melanogaster)
L-Leu [extracellular region]
SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Drosophila melanogaster)
L-Leu [extracellular region]
SLC7A8-mediated uptake of neutral amino acids (Drosophila melanogaster)
ligands of SLC7A8 [extracellular region]
L-Leu [extracellular region]
SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Drosophila melanogaster)
L-Leu [extracellular region]
Transport of small molecules (Gallus gallus)
SLC-mediated transmembrane transport (Gallus gallus)
Transport of bile salts and organic acids, metal ions and amine compounds (Gallus gallus)
Na+/Cl- dependent neurotransmitter transporters (Gallus gallus)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Gallus gallus)
SLC6A14 ligands [extracellular region]
L-Leu [extracellular region]
SLC6A15-mediated amino acid uptake (Gallus gallus)
ligands of SLC6A15 [extracellular region]
L-Leu [extracellular region]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Gallus gallus)
neutral amino acids [extracellular region]
L-Leu [extracellular region]
Transport of inorganic cations/anions and amino acids/oligopeptides (Gallus gallus)
Amino acid transport across the plasma membrane (Gallus gallus)
SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Gallus gallus)
ligands of SLC38A2 [extracellular region]
L-Leu [extracellular region]
SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Gallus gallus)
ligands of SLC43A1 and SLC43A2 [extracellular region]
L-Leu [extracellular region]
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Gallus gallus)
SLC6A14 ligands [extracellular region]
L-Leu [extracellular region]
SLC6A15-mediated amino acid uptake (Gallus gallus)
ligands of SLC6A15 [extracellular region]
L-Leu [extracellular region]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Gallus gallus)
neutral amino acids [extracellular region]
L-Leu [extracellular region]
SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Gallus gallus)
L-Leu [extracellular region]
Disease (Homo sapiens)
Disorders of transmembrane transporters (Homo sapiens)
SLC transporter disorders (Homo sapiens)
Defective SLC6A19 causes Hartnup disorder (HND) (Homo sapiens)
Defective SLC6A19 does not cotransport neutral amino acids, Na+ from extracellular region to cytosol (Homo sapiens)
neutral amino acids [extracellular region]
L-Leu [extracellular region]
Defective SLC7A7 causes lysinuric protein intolerance (LPI) (Homo sapiens)
Defective SLC7A7 does not exchange L-Arg for L-Leu, Na+ across the plasma membrane (Homo sapiens)
L-Leu [extracellular region]
Variant SLC6A14 may confer susceptibility towards obesity (Homo sapiens)
Variant SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Homo sapiens)
SLC6A14 ligands [extracellular region]
L-Leu [extracellular region]
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Tryptophan catabolism (Homo sapiens)
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Homo sapiens)
ligands of SLC7A5 [extracellular region]
L-Leu [extracellular region]
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Na+/Cl- dependent neurotransmitter transporters (Homo sapiens)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Homo sapiens)
SLC6A14 ligands [extracellular region]
L-Leu [extracellular region]
SLC6A15-mediated amino acid uptake (Homo sapiens)
ligands of SLC6A15 [extracellular region]
L-Leu [extracellular region]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Homo sapiens)
neutral amino acids [extracellular region]
L-Leu [extracellular region]
Transport of inorganic cations/anions and amino acids/oligopeptides (Homo sapiens)
Amino acid transport across the plasma membrane (Homo sapiens)
SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Homo sapiens)
ligands of SLC38A2 [extracellular region]
L-Leu [extracellular region]
SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Homo sapiens)
ligands of SLC43A1 and SLC43A2 [extracellular region]
L-Leu [extracellular region]
SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Homo sapiens)
ligands of SLC43A1 and SLC43A2 [extracellular region]
L-Leu [extracellular region]
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Homo sapiens)
SLC6A14 ligands [extracellular region]
L-Leu [extracellular region]
SLC6A15-mediated amino acid uptake (Homo sapiens)
ligands of SLC6A15 [extracellular region]
L-Leu [extracellular region]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Homo sapiens)
neutral amino acids [extracellular region]
L-Leu [extracellular region]
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Homo sapiens)
ligands of SLC7A5 [extracellular region]
L-Leu [extracellular region]
SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Homo sapiens)
L-Leu [extracellular region]
SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Homo sapiens)
L-Leu [extracellular region]
SLC7A8-mediated uptake of neutral amino acids (Homo sapiens)
ligands of SLC7A8 [extracellular region]
L-Leu [extracellular region]
SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Homo sapiens)
L-Leu [extracellular region]
Metabolism (Mus musculus)
Metabolism of amino acids and derivatives (Mus musculus)
Tryptophan catabolism (Mus musculus)
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Mus musculus)
ligands of SLC7A5 [extracellular region]
L-Leu [extracellular region]
Transport of small molecules (Mus musculus)
SLC-mediated transmembrane transport (Mus musculus)
Transport of bile salts and organic acids, metal ions and amine compounds (Mus musculus)
Na+/Cl- dependent neurotransmitter transporters (Mus musculus)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Mus musculus)
SLC6A14 ligands [extracellular region]
L-Leu [extracellular region]
SLC6A15-mediated amino acid uptake (Mus musculus)
ligands of SLC6A15 [extracellular region]
L-Leu [extracellular region]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Mus musculus)
neutral amino acids [extracellular region]
L-Leu [extracellular region]
Transport of inorganic cations/anions and amino acids/oligopeptides (Mus musculus)
Amino acid transport across the plasma membrane (Mus musculus)
SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Mus musculus)
ligands of SLC38A2 [extracellular region]
L-Leu [extracellular region]
SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Mus musculus)
ligands of SLC43A1 and SLC43A2 [extracellular region]
L-Leu [extracellular region]
SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Mus musculus)
ligands of SLC43A1 and SLC43A2 [extracellular region]
L-Leu [extracellular region]
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Mus musculus)
SLC6A14 ligands [extracellular region]
L-Leu [extracellular region]
SLC6A15-mediated amino acid uptake (Mus musculus)
ligands of SLC6A15 [extracellular region]
L-Leu [extracellular region]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Mus musculus)
neutral amino acids [extracellular region]
L-Leu [extracellular region]
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Mus musculus)
ligands of SLC7A5 [extracellular region]
L-Leu [extracellular region]
SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Mus musculus)
L-Leu [extracellular region]
SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Mus musculus)
L-Leu [extracellular region]
SLC7A8-mediated uptake of neutral amino acids (Mus musculus)
ligands of SLC7A8 [extracellular region]
L-Leu [extracellular region]
SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Mus musculus)
L-Leu [extracellular region]
Transport of small molecules (Plasmodium falciparum)
SLC-mediated transmembrane transport (Plasmodium falciparum)
Transport of bile salts and organic acids, metal ions and amine compounds (Plasmodium falciparum)
Na+/Cl- dependent neurotransmitter transporters (Plasmodium falciparum)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Plasmodium falciparum)
SLC6A14 ligands [extracellular region]
L-Leu [extracellular region]
SLC6A15-mediated amino acid uptake (Plasmodium falciparum)
ligands of SLC6A15 [extracellular region]
L-Leu [extracellular region]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Plasmodium falciparum)
neutral amino acids [extracellular region]
L-Leu [extracellular region]
Transport of inorganic cations/anions and amino acids/oligopeptides (Plasmodium falciparum)
Amino acid transport across the plasma membrane (Plasmodium falciparum)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Plasmodium falciparum)
SLC6A14 ligands [extracellular region]
L-Leu [extracellular region]
SLC6A15-mediated amino acid uptake (Plasmodium falciparum)
ligands of SLC6A15 [extracellular region]
L-Leu [extracellular region]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Plasmodium falciparum)
neutral amino acids [extracellular region]
L-Leu [extracellular region]
Metabolism (Rattus norvegicus)
Metabolism of amino acids and derivatives (Rattus norvegicus)
Tryptophan catabolism (Rattus norvegicus)
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Rattus norvegicus)
ligands of SLC7A5 [extracellular region]
L-Leu [extracellular region]
Transport of small molecules (Rattus norvegicus)
SLC-mediated transmembrane transport (Rattus norvegicus)
Transport of bile salts and organic acids, metal ions and amine compounds (Rattus norvegicus)
Na+/Cl- dependent neurotransmitter transporters (Rattus norvegicus)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Rattus norvegicus)
SLC6A14 ligands [extracellular region]
L-Leu [extracellular region]
SLC6A15-mediated amino acid uptake (Rattus norvegicus)
ligands of SLC6A15 [extracellular region]
L-Leu [extracellular region]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Rattus norvegicus)
neutral amino acids [extracellular region]
L-Leu [extracellular region]
Transport of inorganic cations/anions and amino acids/oligopeptides (Rattus norvegicus)
Amino acid transport across the plasma membrane (Rattus norvegicus)
SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Rattus norvegicus)
ligands of SLC38A2 [extracellular region]
L-Leu [extracellular region]
SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Rattus norvegicus)
ligands of SLC43A1 and SLC43A2 [extracellular region]
L-Leu [extracellular region]
SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Rattus norvegicus)
ligands of SLC43A1 and SLC43A2 [extracellular region]
L-Leu [extracellular region]
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Rattus norvegicus)
SLC6A14 ligands [extracellular region]
L-Leu [extracellular region]
SLC6A15-mediated amino acid uptake (Rattus norvegicus)
ligands of SLC6A15 [extracellular region]
L-Leu [extracellular region]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Rattus norvegicus)
neutral amino acids [extracellular region]
L-Leu [extracellular region]
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Rattus norvegicus)
ligands of SLC7A5 [extracellular region]
L-Leu [extracellular region]
SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Rattus norvegicus)
L-Leu [extracellular region]
SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Rattus norvegicus)
L-Leu [extracellular region]
SLC7A8-mediated uptake of neutral amino acids (Rattus norvegicus)
ligands of SLC7A8 [extracellular region]
L-Leu [extracellular region]
SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Rattus norvegicus)
L-Leu [extracellular region]
Transport of small molecules (Saccharomyces cerevisiae)
SLC-mediated transmembrane transport (Saccharomyces cerevisiae)
Transport of inorganic cations/anions and amino acids/oligopeptides (Saccharomyces cerevisiae)
Amino acid transport across the plasma membrane (Saccharomyces cerevisiae)
SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Saccharomyces cerevisiae)
ligands of SLC38A2 [extracellular region]
L-Leu [extracellular region]
SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Saccharomyces cerevisiae)
L-Leu [extracellular region]
Metabolism (Sus scrofa)
Metabolism of amino acids and derivatives (Sus scrofa)
Tryptophan catabolism (Sus scrofa)
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Sus scrofa)
ligands of SLC7A5 [extracellular region]
L-Leu [extracellular region]
Transport of small molecules (Sus scrofa)
SLC-mediated transmembrane transport (Sus scrofa)
Transport of bile salts and organic acids, metal ions and amine compounds (Sus scrofa)
Na+/Cl- dependent neurotransmitter transporters (Sus scrofa)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Sus scrofa)
SLC6A14 ligands [extracellular region]
L-Leu [extracellular region]
SLC6A15-mediated amino acid uptake (Sus scrofa)
ligands of SLC6A15 [extracellular region]
L-Leu [extracellular region]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Sus scrofa)
neutral amino acids [extracellular region]
L-Leu [extracellular region]
Transport of inorganic cations/anions and amino acids/oligopeptides (Sus scrofa)
Amino acid transport across the plasma membrane (Sus scrofa)
SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Sus scrofa)
ligands of SLC38A2 [extracellular region]
L-Leu [extracellular region]
SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Sus scrofa)
ligands of SLC43A1 and SLC43A2 [extracellular region]
L-Leu [extracellular region]
SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Sus scrofa)
ligands of SLC43A1 and SLC43A2 [extracellular region]
L-Leu [extracellular region]
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Sus scrofa)
SLC6A14 ligands [extracellular region]
L-Leu [extracellular region]
SLC6A15-mediated amino acid uptake (Sus scrofa)
ligands of SLC6A15 [extracellular region]
L-Leu [extracellular region]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Sus scrofa)
neutral amino acids [extracellular region]
L-Leu [extracellular region]
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Sus scrofa)
ligands of SLC7A5 [extracellular region]
L-Leu [extracellular region]
SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Sus scrofa)
L-Leu [extracellular region]
SLC7A8-mediated uptake of neutral amino acids (Sus scrofa)
ligands of SLC7A8 [extracellular region]
L-Leu [extracellular region]
SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Sus scrofa)
L-Leu [extracellular region]
Metabolism (Xenopus tropicalis)
Metabolism of amino acids and derivatives (Xenopus tropicalis)
Tryptophan catabolism (Xenopus tropicalis)
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Xenopus tropicalis)
ligands of SLC7A5 [extracellular region]
L-Leu [extracellular region]
Transport of small molecules (Xenopus tropicalis)
SLC-mediated transmembrane transport (Xenopus tropicalis)
Transport of bile salts and organic acids, metal ions and amine compounds (Xenopus tropicalis)
Na+/Cl- dependent neurotransmitter transporters (Xenopus tropicalis)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Xenopus tropicalis)
SLC6A14 ligands [extracellular region]
L-Leu [extracellular region]
SLC6A15-mediated amino acid uptake (Xenopus tropicalis)
ligands of SLC6A15 [extracellular region]
L-Leu [extracellular region]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Xenopus tropicalis)
neutral amino acids [extracellular region]
L-Leu [extracellular region]
Transport of inorganic cations/anions and amino acids/oligopeptides (Xenopus tropicalis)
Amino acid transport across the plasma membrane (Xenopus tropicalis)
SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Xenopus tropicalis)
ligands of SLC38A2 [extracellular region]
L-Leu [extracellular region]
SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Xenopus tropicalis)
ligands of SLC43A1 and SLC43A2 [extracellular region]
L-Leu [extracellular region]
SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Xenopus tropicalis)
ligands of SLC43A1 and SLC43A2 [extracellular region]
L-Leu [extracellular region]
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Xenopus tropicalis)
SLC6A14 ligands [extracellular region]
L-Leu [extracellular region]
SLC6A15-mediated amino acid uptake (Xenopus tropicalis)
ligands of SLC6A15 [extracellular region]
L-Leu [extracellular region]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Xenopus tropicalis)
neutral amino acids [extracellular region]
L-Leu [extracellular region]
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Xenopus tropicalis)
ligands of SLC7A5 [extracellular region]
L-Leu [extracellular region]
SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Xenopus tropicalis)
L-Leu [extracellular region]
SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Xenopus tropicalis)
L-Leu [extracellular region]
SLC7A8-mediated uptake of neutral amino acids (Xenopus tropicalis)
ligands of SLC7A8 [extracellular region]
L-Leu [extracellular region]
SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Xenopus tropicalis)
L-Leu [extracellular region]
External Reference Information
External Reference
L-leucine zwitterion [ChEBI:57427]
Participates
as an input of
Defective SLC7A7 does not exchange L-Arg for L-Leu, Na+ across the plasma membrane (Homo sapiens)
SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Drosophila melanogaster)
SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Xenopus tropicalis)
SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Danio rerio)
SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Bos taurus)
SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Canis familiaris)
SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Rattus norvegicus)
SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Mus musculus)
SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Homo sapiens)
SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Drosophila melanogaster)
SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Xenopus tropicalis)
SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Danio rerio)
SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Sus scrofa)
SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Bos taurus)
SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Rattus norvegicus)
SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Mus musculus)
SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Homo sapiens)
as a member of
ligands of SLC6A15 [extracellular region]
SLC6A14 ligands [extracellular region]
ligands of SLC7A8 [extracellular region]
neutral amino acids [extracellular region]
ligands of SLC7A5 [extracellular region]
ligands of SLC38A2 [extracellular region]
ligands of SLC43A1 and SLC43A2 [extracellular region]
as an output of
SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Saccharomyces cerevisiae)
SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Drosophila melanogaster)
SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Gallus gallus)
SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Xenopus tropicalis)
SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Sus scrofa)
SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Bos taurus)
SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Canis familiaris)
SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Rattus norvegicus)
SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Mus musculus)
SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Homo sapiens)
Other forms of this molecule
L-Leu [cytosol]
L-Leu [mitochondrial matrix]
Cross References
COMPOUND
C00123
ZINC
ZINC000003645145
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