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Luteinizing hormone is a heterodimer
Stable Identifier
R-HSA-378956
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Peptide hormone biosynthesis (Homo sapiens)
Glycoprotein hormones (Homo sapiens)
Luteinizing hormone is a heterodimer (Homo sapiens)
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Luteinizing hormone (LH, lutropin) is a hormone produced by the anterior pituitary gland. In females it can trigger ovulation whereas in males it stimulates testosterone production. Like other glycoproteins, lutropin is composed of a common alpha subunit bound to a unique beta subunit (Sairam MR and Li CH, 1975). The beta subunit is responsible for lutropin's interaction with the LH receptor. N-Linked oligosaccharides terminating with the sequence SO(4)-4-GalNAcbeta1,4-GlcNAcbeta1,2-Manalpha are present on the pituitary hormones LH, thyrotropin, and pro-opiomelanocortin. These sulfated structures are essential for their biologic function (Fares 2006).
Literature References
PubMed ID
Title
Journal
Year
1191677
Human pituitary lutropin. Isolation, properties, and the complete amino acid sequence of the beta-subunit
Li, CH
,
Sairam, MR
Biochim Biophys Acta
1975
16527410
The role of O-linked and N-linked oligosaccharides on the structure-function of glycoprotein hormones: development of agonists and antagonists
Fares, F
Biochim. Biophys. Acta
2006
Participants
Input
CGA [extracellular region]
(Homo sapiens)
LHB [extracellular region]
(Homo sapiens)
Output
glyco-Lutropin [extracellular region]
(Homo sapiens)
Participates
as an event of
Glycoprotein hormones (Homo sapiens)
Orthologous Events
Luteinizing hormone is a heterodimer (Bos taurus)
Luteinizing hormone is a heterodimer (Danio rerio)
Luteinizing hormone is a heterodimer (Mus musculus)
Luteinizing hormone is a heterodimer (Rattus norvegicus)
Luteinizing hormone is a heterodimer (Sus scrofa)
Authored
Jassal, B (2008-10-01)
Reviewed
D'Eustachio, P (2008-11-29)
Created
Jassal, B (2008-10-01)
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