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Glycoprotein hormones
Stable Identifier
R-HSA-209822
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Peptide hormone biosynthesis (Homo sapiens)
Glycoprotein hormones (Homo sapiens)
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More complex protein hormones have carbohydrate side chains and are called glycoprotein hormones. Hormones in this class are Follicle-stimulating hormone (FSH; follitropin), Luteinizing hormone (LH), Thyroid-stimulating hormone (TSH; thyrotropin) and human chorionic gonadotropin (hCG). The alpha subunit of glycoprotein hormones is a 92 aa peptide and serves as the alpha subunit for FSH, LH, hCG and TSH (Fiddes JC and Goodman HM, 1981). The beta subunits for these hormones are unique and confer biological specificity to them. These two subunits combine via disulphide bonding to produce the mature glycoprotein hormone dimer.
Literature References
PubMed ID
Title
Journal
Year
6267989
Glycoprotein hormones: structure and function
Parsons, TF
,
Pierce, JG
Annu Rev Biochem
1981
Participants
Events
CGA and CGB3 bind to form Human chorionic gonadotropin (hCG)
(Homo sapiens)
Luteinizing hormone is a heterodimer
(Homo sapiens)
Thyrotropin is a heterodimer
(Homo sapiens)
Follitropin is a heterodimer
(Homo sapiens)
Participates
as an event of
Peptide hormone biosynthesis (Homo sapiens)
Orthologous Events
Glycoprotein hormones (Bos taurus)
Glycoprotein hormones (Canis familiaris)
Glycoprotein hormones (Danio rerio)
Glycoprotein hormones (Gallus gallus)
Glycoprotein hormones (Mus musculus)
Glycoprotein hormones (Rattus norvegicus)
Glycoprotein hormones (Sus scrofa)
Glycoprotein hormones (Xenopus tropicalis)
Authored
Jassal, B (2008-10-01)
Reviewed
D'Eustachio, P (2008-11-29)
Created
Jassal, B (2008-01-08)
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