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LHB [extracellular region]
Stable Identifier
R-HSA-378982
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Lutropin subunit beta, LSHB_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Metabolism of steroid hormones (Homo sapiens)
Androgen biosynthesis (Homo sapiens)
HSD17B3-like proteins reducde ANDST to TEST (Homo sapiens)
glyco-Lutropin [extracellular region] (Homo sapiens)
LHB [extracellular region] (Homo sapiens)
Mineralocorticoid biosynthesis (Homo sapiens)
Pregn-5-ene-3,20-dione isomerizes to progesterone (Homo sapiens)
glyco-Lutropin [extracellular region] (Homo sapiens)
LHB [extracellular region] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Peptide hormone biosynthesis (Homo sapiens)
Glycoprotein hormones (Homo sapiens)
Luteinizing hormone is a heterodimer (Homo sapiens)
LHB [extracellular region] (Homo sapiens)
glyco-Lutropin [extracellular region] (Homo sapiens)
LHB [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
LH receptor:LH [plasma membrane] (Homo sapiens)
glyco-Lutropin [extracellular region] (Homo sapiens)
LHB [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
LH receptor:LH [plasma membrane] (Homo sapiens)
glyco-Lutropin [extracellular region] (Homo sapiens)
LHB [extracellular region] (Homo sapiens)
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
LH receptor:LH [plasma membrane] (Homo sapiens)
glyco-Lutropin [extracellular region] (Homo sapiens)
LHB [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
LH receptor:LH [plasma membrane] (Homo sapiens)
glyco-Lutropin [extracellular region] (Homo sapiens)
LHB [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
LH receptor:LH [plasma membrane] (Homo sapiens)
glyco-Lutropin [extracellular region] (Homo sapiens)
LHB [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gs [extracellular region] (Homo sapiens)
glyco-Lutropin [extracellular region] (Homo sapiens)
LHB [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Hormone ligand-binding receptors (Homo sapiens)
Luteinizing hormone receptor can bind LH (Homo sapiens)
LH receptor:LH [plasma membrane] (Homo sapiens)
glyco-Lutropin [extracellular region] (Homo sapiens)
LHB [extracellular region] (Homo sapiens)
glyco-Lutropin [extracellular region] (Homo sapiens)
LHB [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01229 LHB
Gene Names
LHB
Chain
signal peptide:1-20, chain:21-141
Reference Genes
BioGPS Gene:3972 LHB
COSMIC (genes):LHB LHB
CTD Gene:3972 LHB
dbSNP Gene:3972 LHB
ENSEMBL:ENSG00000104826 LHB
ENSEMBL:ENSG00000104826.15 LHB
HGNC:6584 LHB
KEGG Gene (Homo sapiens):3972 LHB
Monarch:3972 LHB
NCBI Gene:3972 LHB
OMIM:152780 LHB
UCSC:P01229 LHB
Reference Transcript
RefSeq:NM_000894.2 LHB
Other Identifiers
11715313_s_at
214471_3p_x_at
214471_PM_x_at
214471_x_at
35378_at
3867574
3867575
3867576
3867578
3867616
3867640
3972
697_f_at
8038278
A_23_P218505
GE558199
GO:0005102
GO:0005179
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005794
GO:0005796
GO:0006629
GO:0006701
GO:0007165
GO:0007186
GO:0007267
GO:0008584
GO:0009755
GO:0022414
GO:0023052
GO:0043226
GO:0048018
GO:0048856
GO:0051716
GO:0061696
GO:0098772
HMNXSV003001944
Hs.154704.0.S1_3p_at
Hs.154704.0.S1_3p_x_at
ILMN_1765187
PH_hs_0029247
TC19001704.hg
Participates
as an input of
Luteinizing hormone is a heterodimer (Homo sapiens)
as a component of
glyco-Lutropin [extracellular region] (Homo sapiens)
Other forms of this molecule
S-glyco-LHB [Golgi lumen]
LHB [Golgi lumen]
Inferred To
Lhb [extracellular region]
(Mus musculus)
Lhb [extracellular region]
(Rattus norvegicus)
lhbeta1 [extracellular region]
(Danio rerio)
LHB [extracellular region]
(Bos taurus)
LHB [extracellular region]
(Sus scrofa)
Homologues of LHB [extracellular region]
(Sus scrofa)
Modified Residues
Name
glycosylated residue (N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl group) at 50
Coordinate
50
Modification
N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl group
PsiMod Name
glycosylated residue
PsiMod Definition
A protein modification that effectively replaces a hydrogen atom with an carbohydrate-like group through a glycosidic bond.
Cross References
RefSeq
NP_000885.1
OpenTargets
ENSG00000104826
HPA
ENSG00000104826-LHB
GeneCards
P01229
Ensembl
ENST00000649238
,
ENSG00000104826
,
ENSP00000497294
PRO
P01229
Pharos - Targets
P01229
Orphanet
16353
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96EQ0 SGTB
0.556
3
UniProt:Q9P121-3 NTM
0.556
3
UniProt:Q13643 FHL3
0.556
3
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