Reactome | LHB [extracellular region]

LHB [extracellular region]

Stable Identifier

R-HSA-378982

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Lutropin subunit beta, LSHB_HUMAN

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (s) signalling events (Homo sapiens)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        LH receptor:LH [plasma membrane] (Homo sapiens)
        
        glyco-Lutropin [extracellular region] (Homo sapiens)
        
        LHB [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        LH receptor:LH [plasma membrane] (Homo sapiens)
        
        glyco-Lutropin [extracellular region] (Homo sapiens)
        
        LHB [extracellular region] (Homo sapiens)
      - Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        LH receptor:LH [plasma membrane] (Homo sapiens)
        
        glyco-Lutropin [extracellular region] (Homo sapiens)
        
        LHB [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        LH receptor:LH [plasma membrane] (Homo sapiens)
        
        glyco-Lutropin [extracellular region] (Homo sapiens)
        
        LHB [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        LH receptor:LH [plasma membrane] (Homo sapiens)
        
        glyco-Lutropin [extracellular region] (Homo sapiens)
        
        LHB [extracellular region] (Homo sapiens)
        
        Ligands of GPCRs that activate Gs [extracellular region] (Homo sapiens)
        
        glyco-Lutropin [extracellular region] (Homo sapiens)
        
        LHB [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Hormone ligand-binding receptors (Homo sapiens)
        
        Luteinizing hormone receptor can bind LH (Homo sapiens)
        
        LH receptor:LH [plasma membrane] (Homo sapiens)
        
        glyco-Lutropin [extracellular region] (Homo sapiens)
        
        LHB [extracellular region] (Homo sapiens)
        
        glyco-Lutropin [extracellular region] (Homo sapiens)
        
        LHB [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P01229 LHB

Gene Names

LHB

Chain

signal peptide:1-20, chain:21-141

Reference Genes

BioGPS Gene:3972 LHB

COSMIC (genes):LHB LHB

CTD Gene:3972 LHB

dbSNP Gene:3972 LHB

ENSEMBL:ENSG00000104826 LHB

HGNC:6584 LHB

KEGG:hsa:3972 LHB

Monarch:3972 LHB

NCBI Gene:3972 LHB

OMIM:152780 LHB

UCSC:P01229 LHB

Reference Transcript

RefSeq:NM_000894.2 LHB

Other Identifiers

11715313_s_at

16874182

214471_3p_x_at

214471_PM_x_at

214471_x_at

35378_at

3867574

3867575

3867576

3867578

3867579

3867616

3867640

3972

697_f_at

8038278

A_23_P218505

GE558199

GO:0005102

GO:0005179

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005796

GO:0006629

GO:0006701

GO:0007165

GO:0007186

GO:0007267

GO:0008584

GO:0009755

GO:0022414

GO:0023052

GO:0048018

GO:0048856

GO:0061696

GO:0098772

HMNXSV003001944

Hs.154704.0.S1_3p_at

Hs.154704.0.S1_3p_x_at

ILMN_1765187

PH_hs_0029247

TC19001704.hg

Participates

as an input of

Luteinizing hormone is a heterodimer (Homo sapiens)

as a component of

glyco-Lutropin [extracellular region] (Homo sapiens)

Other forms of this molecule

S-glyco-LHB [Golgi lumen]

LHB [Golgi lumen]

Inferred To

Lhb [extracellular region] (Mus musculus)

Lhb [extracellular region] (Rattus norvegicus)

LHB [extracellular region] (Bos taurus)

LHB [extracellular region] (Sus scrofa)

lhb [extracellular region] (Danio rerio)

Modified Residues

Name

glycosylated residue (N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl group) at 50

Coordinate

Modification

N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl group

PsiMod Name

glycosylated residue

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with an carbohydrate-like group through a glycosidic bond.

Cross References

RefSeq

NP_000885.1

ENSEMBL

ENSG00000104826, ENST00000649238, ENSP00000497294

OpenTargets

ENSG00000104826

GeneCards

LHB

HPA

ENSG00000104826-LHB

PRO

P01229

Pharos - Targets

P01229

GlyGen

P01229

Orphanet

LHB

Interactors (3)

Accession	Confidence Score	Evidence (IntAct)
UniProt:Q96EQ0 SGTB	0.556	3
UniProt:Q9P121-3 NTM	0.556	3
UniProt:Q13643 FHL3	0.556	3