Thyrotropin is a heterodimer

Stable Identifier
R-HSA-378952
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Thyrotropin is a heterodimer
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Thyroid-stimulating hormone (TSH, thyrotropin) is a glycopeptide hormone synthesized and secreted by thyrotrope cells in the anterior pituitary gland which regulates the endocrine function of the thyroid gland. Like other glycoprotein hormones, TSH consists of a common alpha subunit and a beta subunit unique to TSH which determines its specificty. TSH binds to TSH receptor to stimulate the release of the hormones thyroxine (T4) and triiodothyronine (T3) (Chin and Habener 1981).
Literature References
PubMed ID Title Journal Year
7215288 Thyroid-stimulating hormone subunits: evidence from endoglycosidase-H cleavage for late presecretory glycosylation

Chin, WW, Habener, JF

Endocrinology 1981
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Orthologous Events
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Authored
Jassal, B  (2008-10-01)
Reviewed
D'Eustachio, P  (2008-11-29)
Created
Jassal, B  (2008-10-01)
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