DSB inducing agents induce double strand DNA breaks

Stable Identifier
R-HSA-3785704
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
nucleoplasm
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DSB inducing agents induce double strand DNA breaks
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Reactive oxygen species (ROS) induce DNA double-strand breaks (DSBs) (Yu and Anderson 1997) in cells undergoing oxidative stress. In addition to ROS, DSBs can also be directly generated by ionizing radiation. Agents that interfere with the progression of replication forks, such as topoisomerase poisons used in chemotherapy, induce DSBs indirectly (Curtin 2012).

Literature References
PubMed ID Title Journal Year
9357549 Reactive oxygen species-induced DNA damage and its modification: a chemical investigation

Anderson, D, Yu, TW

Mutat. Res. 1997
23175119 DNA repair dysregulation from cancer driver to therapeutic target

Curtin, NJ

Nat. Rev. Cancer 2012
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Authored
Orlic-Milacic, M  (2013-07-15)
Reviewed
Borowiec, JA  (2015-06-12)
Samarajiwa, S  (2013-09-03)
Created
Orlic-Milacic, M  (2013-07-03)
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