Reactive oxygen species (ROS) induce DNA double-strand breaks (DSBs) (Yu and Anderson 1997) in cells undergoing oxidative stress. In addition to ROS, DSBs can also be directly generated by ionizing radiation. Agents that interfere with the progression of replication forks, such as topoisomerase poisons used in chemotherapy, induce DSBs indirectly (Curtin 2012).
Anderson, D, Yu, TW
Curtin, NJ
© 2022 Reactome