Receptor CXCR3 binds ligands CXCL9 to 11

Stable Identifier
R-HSA-374248
Type
Reaction [binding]
Species
Homo sapiens
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CXCR3 (Loetscher M et al, 1996) is predominantly expressed on T lymphocytes, and on other lymphocytes (some B cells and NK cells). It is highly induced following cell activation. There are three isoforms, CXCR3-A, CXCR3-B and CXCR3-alt. CXCR3 binds to three highly related ligands in mammals, CXCL9, CXCL10 and CXCL11 (Xanthou G et al, 2003). The ligands then elicit their chemoattractant functions. CXCL9 (CMK; monokine induced by gamma-interferon, MIG; SCYB9) is a T cell chemoattractant (Farber JM, 1993). CXCL10 (IP-10) (Booth V et al, 2002) is secreted by monocytes, endothelial cells and fibroblasts in response to gamma-interferon. It can act as a chemoattractant for monocytes, macrophages, T cells, NK cells and dendritic cells, promote T cell adhesion to endothelial cells and inhibit angiogenesis and bone marrow colony formation. CXCL11 (I-TAC,; iIP-9) (Cole KE et al, 1998) is highly expressed in peripheral blood leukocytes, pancreas and liver. It is regulated by interferon and has potent chemoattractant activity for interleukin-2-activated T cells.

Literature References
PubMed ID Title Journal Year
12884299 CCR3 functional responses are regulated by both CXCR3 and its ligands CXCL9, CXCL10 and CXCL11

Xanthou, G, Duchesnes, CE, Williams, TJ, Pease, JE

Eur J Immunol 2003
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