Reactome | CCR1 [plasma membrane]

CCR1 [plasma membrane]

Stable Identifier

R-HSA-373107

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

C-C chemokine receptor type 1, CCR1_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Homo sapiens)
        
        CCR5, CCR1 [plasma membrane] (Homo sapiens)
        
        CCR1 [plasma membrane] (Homo sapiens)
        
        CCR1,2,8:CCL16 [plasma membrane] (Homo sapiens)
        
        CCR1,2,8 [plasma membrane] (Homo sapiens)
        
        CCR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Homo sapiens)
        
        CCR5, CCR1 [plasma membrane] (Homo sapiens)
        
        CCR1 [plasma membrane] (Homo sapiens)
        
        CCR1,2,8:CCL16 [plasma membrane] (Homo sapiens)
        
        CCR1,2,8 [plasma membrane] (Homo sapiens)
        
        CCR1 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Homo sapiens)
        
        CCR5, CCR1 [plasma membrane] (Homo sapiens)
        
        CCR1 [plasma membrane] (Homo sapiens)
        
        CCR1,2,8:CCL16 [plasma membrane] (Homo sapiens)
        
        CCR1,2,8 [plasma membrane] (Homo sapiens)
        
        CCR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Homo sapiens)
        
        CCR5, CCR1 [plasma membrane] (Homo sapiens)
        
        CCR1 [plasma membrane] (Homo sapiens)
        
        CCR1,2,8:CCL16 [plasma membrane] (Homo sapiens)
        
        CCR1,2,8 [plasma membrane] (Homo sapiens)
        
        CCR1 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Homo sapiens)
        
        CCR5, CCR1 [plasma membrane] (Homo sapiens)
        
        CCR1 [plasma membrane] (Homo sapiens)
        
        CCR1,2,8:CCL16 [plasma membrane] (Homo sapiens)
        
        CCR1,2,8 [plasma membrane] (Homo sapiens)
        
        CCR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Homo sapiens)
        
        CCR5, CCR1 [plasma membrane] (Homo sapiens)
        
        CCR1 [plasma membrane] (Homo sapiens)
        
        CCR1,2,8:CCL16 [plasma membrane] (Homo sapiens)
        
        CCR1,2,8 [plasma membrane] (Homo sapiens)
        
        CCR1 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Chemokine receptors bind chemokines (Homo sapiens)
        
        Receptors CCR1, 2 and 8 bind CCL16 ligand (Homo sapiens)
        
        CCR1,2,8 [plasma membrane] (Homo sapiens)
        
        CCR1 [plasma membrane] (Homo sapiens)
        
        CCR1,2,8:CCL16 [plasma membrane] (Homo sapiens)
        
        CCR1,2,8 [plasma membrane] (Homo sapiens)
        
        CCR1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P32246 CCR1

Gene Names

CCR1, CMKBR1, CMKR1, SCYAR1

Chain

chain:1-355

Reference Genes

BioGPS Gene:1230 CCR1

COSMIC (genes):CCR1 CCR1

CTD Gene:1230 CCR1

dbSNP Gene:1230 CCR1

ENSEMBL:ENSG00000163823 CCR1

HGNC:1602 CCR1

KEGG:hsa:1230 CCR1

Monarch:1230 CCR1

NCBI Gene:1230 CCR1

OMIM:601159 CCR1

UCSC:P32246 CCR1

Reference Transcript

RefSeq:NM_001295.2 CCR1

Other Identifiers

1128_s_at

11725444_at

1230

16952874

205098_PM_at

205098_at

205099_PM_s_at

205099_s_at

2672097

2672098

2672099

2672102

39994_at

8086600

91043_at

A_23_P6849

A_24_P148717

D10925_at

GE57048

GO:0002376

GO:0002407

GO:0002548

GO:0003824

GO:0004435

GO:0004930

GO:0004950

GO:0005515

GO:0005737

GO:0005886

GO:0006816

GO:0006874

GO:0006887

GO:0006935

GO:0006954

GO:0006955

GO:0007155

GO:0007166

GO:0007186

GO:0007187

GO:0007204

GO:0007267

GO:0009611

GO:0009897

GO:0010629

GO:0016020

GO:0016192

GO:0016493

GO:0016787

GO:0019221

GO:0019722

GO:0019957

GO:0023052

GO:0030335

GO:0030502

GO:0035717

GO:0045672

GO:0048870

GO:0051928

GO:0060089

GO:0060326

GO:0070098

GO:0070374

GO:0071791

GO:0090026

HMNXSV003040809

Hs.301921.0.S3_3p_at

ILMN_1678833

L09230_s_at

PH_hs_0032575

TC03001355.hg

g4502630_3p_a_at

Participates

as a member of

Inferred To

npr-32 [plasma membrane] (Caenorhabditis elegans)

Ccr1 [plasma membrane] (Mus musculus)

Ccr1l1 [plasma membrane] (Rattus norvegicus)

ccr3 [plasma membrane] (Xenopus tropicalis)

CCR1 [plasma membrane] (Bos taurus)

CCR1 [plasma membrane] (Canis familiaris)

CCR1 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_001286.1

Guide to Pharmacology - Targets

ENSEMBL

ENST00000296140, ENSP00000296140, ENSG00000163823

OpenTargets

ENSG00000163823

ZINC - FDA approved

CCR1_HUMAN

ZINC - Substances

CCR1_HUMAN

ZINC - Biogenic

CCR1_HUMAN

ZINC target

P32246

PRO

P32246

GlyGen

P32246

PDB

7VLA, 7VL9, 7VL8

ZINC - Metabolites

CCR1_HUMAN

GeneCards

CCR1

HPA

ENSG00000163823-CCR1

Pharos - Targets

P32246

Orphanet

CCR1

ZINC - Predictions - Purchasable

CCR1_HUMAN

HMDB Protein

HMDBP07574

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P17677 GAP43	2	GAP43 [plasma membrane] (R-HSA-452888) PALM-C3,4-GAP43 [plasma membrane] (R-HSA-8933482)	0.527	2
UniProt:Q9NWQ8 PAG1	2	PAG1 [plasma membrane] (R-HSA-180500) p-Y317-PAG1 [plasma membrane] (R-HSA-180494)	0.527	2
UniProt:P13501 CCL5	1	CCL5(24-91) [extracellular region] (R-HSA-373108)	0.499	2
UniProt:P02686 MBP	1	MBP [cytosol] (R-HSA-9614770)	0.454	2
UniProt:P04156 PRNP	2	PRNP [plasma membrane] (R-HSA-375060) PRNP [cytosol] (R-HSA-9617597)	0.454	2

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