Receptor CCR6 binds CCL20 ligand

Stable Identifier
R-HSA-373087
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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CCR6 (Baba M et al, 1997) is expressed on inactive memory T-cells and on Th17 cells. CCR6 is down-regulated in activated T-cells. CCL20 (macrophage inflammatory protein 3-alpha, MIP 3-alpha) binds and activates CCR6 and it does not share the binding site of CCR6 with any other chemokine.

Literature References
PubMed ID Title Journal Year
12149255 The structure of human macrophage inflammatory protein-3alpha /CCL20. Linking antimicrobial and CC chemokine receptor-6-binding activities with human beta-defensins

Hoover, DM, Boulegue, C, Yang, D, Oppenheim, JJ, Tucker, K, Lu, W, Lubkowski, J

J Biol Chem 2002
9169459 Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC

Baba, M, Imai, T, Nishimura, M, Kakizaki, M, Takagi, S, Hieshima, K, Nomiyama, H, Yoshie, O

J Biol Chem 1997
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