Reactome | Receptor CCR6 binds CCL20 ligand

Receptor CCR6 binds CCL20 ligand

Stable Identifier

R-HSA-373087

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Chemokine receptors bind chemokines (Homo sapiens)
        
        Receptor CCR6 binds CCL20 ligand (Homo sapiens)

General

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CCR6 (Baba M et al, 1997) is expressed on inactive memory T-cells and on Th17 cells. CCR6 is down-regulated in activated T-cells. CCL20 (macrophage inflammatory protein 3-alpha, MIP 3-alpha) binds and activates CCR6 and it does not share the binding site of CCR6 with any other chemokine.

Literature References

PubMed ID	Title	Journal	Year
12149255	The structure of human macrophage inflammatory protein-3alpha /CCL20. Linking antimicrobial and CC chemokine receptor-6-binding activities with human beta-defensins Hoover, DM, Boulegue, C, Yang, D, Oppenheim, JJ, Tucker, K, Lu, W, Lubkowski, J	J Biol Chem	2002
9169459	Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC Baba, M, Imai, T, Nishimura, M, Kakizaki, M, Takagi, S, Hieshima, K, Nomiyama, H, Yoshie, O	J Biol Chem	1997