Reactome | Receptor CCR7 binds CCL19 and 21 ligands

Receptor CCR7 binds CCL19 and 21 ligands

Stable Identifier

R-HSA-373071

Type

Reaction

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Chemokine receptors bind chemokines (Homo sapiens)
        
        Receptor CCR7 binds CCL19 and 21 ligands (Homo sapiens)

Summation

CCR7 (Epstein-Barr virus-induced gene 1, EBI1) (Birkenbach M, 1993; Schweickart VL et al, 1994) plays an important role in the trafficking of B and T lymphocytes and dendritic cells across high endothelial venules. Both CCL19 (Macrophage inflammatory protein 3 beta, MIP-3-beta; EBI1-ligand chemokine, ELC) (Yoshida R et al, 1997) and CCL21 (Secondary lymphoid-tissue chemokine, SLC; Beta chemokine exodus-2) (Yoshida R et al, 1998) bind specifically to CCR7.

Literature References

PubMed ID	Title	Journal	Year
7851893	Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2 Schweickart, VL, Raport, CJ, Godiska, R, Byers, MG, Shows, TB, Gray, PW	Genomics	1994
8383238	Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors Birkenbach, M, Josefsen, K, Yalamanchili, R, Lenoir, G, Kieff, E	J Virol	1993