Receptor CCR7 binds CCL19 and 21 ligands

Stable Identifier
R-HSA-373071
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

CCR7 (Epstein-Barr virus-induced gene 1, EBI1) (Birkenbach M, 1993; Schweickart VL et al, 1994) plays an important role in the trafficking of B and T lymphocytes and dendritic cells across high endothelial venules. Both CCL19 (Macrophage inflammatory protein 3 beta, MIP-3-beta; EBI1-ligand chemokine, ELC) (Yoshida R et al, 1997) and CCL21 (Secondary lymphoid-tissue chemokine, SLC; Beta chemokine exodus-2) (Yoshida R et al, 1998) bind specifically to CCR7.

Literature References
PubMed ID Title Journal Year
7851893 Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2

Schweickart, VL, Raport, CJ, Godiska, R, Byers, MG, Shows, TB, Gray, PW

Genomics 1994
8383238 Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors

Birkenbach, M, Josefsen, K, Yalamanchili, R, Lenoir, G, Kieff, E

J Virol 1993
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