SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine

Stable Identifier
Reaction [transition]
Homo sapiens
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SLC38A3 (SN1), associated with the plasma membrane, mediates the uptake of glutamine, histidine, and, with lower efficiency, alanine and asparagine. Uptake of one molecule of amino acid is coupled to the uptake of two sodium ions and the export of one H+. Northern blotting experiments indicate gene expression in liver and kidney, and at much lower levels in brain, lung, skeletal muscle, spleen, stomach, testis, kidney, and intestine (Fei et al. 2000; Nakanishi et al. 2001).
Literature References
PubMed ID Title Journal Year
11243884 Structure, function, and tissue expression pattern of human SN2, a subtype of the amino acid transport system N

Martindale, RG, Sugawara, M, Ganapathy, ME, Leibach, FH, Nakanishi, T, Ganapathy, V, Huang, W, Prasad, PD

Biochem Biophys Res Commun 2001
10823827 Primary structure, genomic organization, and functional and electrogenic characteristics of human system N 1, a Na+- and H+-coupled glutamine transporter

Sugawara, M, Leibach, FH, Nakanishi, T, Ganapathy, V, Huang, W, Prasad, PD, Wang, H, Fei, YJ

J Biol Chem 2000
Catalyst Activity

amino acid transmembrane transporter activity of SLC38A3 [plasma membrane]

Orthologous Events
Cross References
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