Reactome | SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine

SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine

Stable Identifier

R-HSA-352174

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine

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SLC38A3 (SN1), associated with the plasma membrane, mediates the uptake of glutamine, histidine, and, with lower efficiency, alanine and asparagine. Uptake of one molecule of amino acid is coupled to the uptake of two sodium ions and the export of one H+. Northern blotting experiments indicate gene expression in liver and kidney, and at much lower levels in brain, lung, skeletal muscle, spleen, stomach, testis, kidney, and intestine (Fei et al. 2000; Nakanishi et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11243884	Structure, function, and tissue expression pattern of human SN2, a subtype of the amino acid transport system N Martindale, RG, Sugawara, M, Ganapathy, ME, Leibach, FH, Nakanishi, T, Ganapathy, V, Huang, W, Prasad, PD	Biochem Biophys Res Commun	2001
10823827	Primary structure, genomic organization, and functional and electrogenic characteristics of human system N 1, a Na+- and H+-coupled glutamine transporter Sugawara, M, Leibach, FH, Nakanishi, T, Ganapathy, V, Huang, W, Prasad, PD, Wang, H, Fei, YJ	J Biol Chem	2000