Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine

Stable Identifier
R-HSA-351215
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor.
Literature References
PubMed ID Title Journal Year
2069720 Human spermidine synthase gene: structure and chromosomal localization

Alhonen, L, Myöhänen, S, Wahlfors, J, Kauppinen, L, Jänne, J

DNA Cell Biol 1991
Participants
Input
Output
Participates
as an event of
Catalyst Activity

spermidine synthase activity of SRM [cytosol]

Physical Entity
SRM [cytosol] (Homo sapiens)
Activity
spermidine synthase activity (GO:0004766)
Orthologous Events
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Bos taurus)
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Caenorhabditis elegans)
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Canis familiaris)
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Dictyostelium discoideum)
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Drosophila melanogaster)
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Gallus gallus)
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Mus musculus)
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Plasmodium falciparum)
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Rattus norvegicus)
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Saccharomyces cerevisiae)
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Schizosaccharomyces pombe)
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Sus scrofa)
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Xenopus tropicalis)
Cross References
Rhea
Authored
Gopinathrao, G  (2008-05-21)
Reviewed
D'Eustachio, P  (2008-06-12)
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