Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine

Stable Identifier
R-HSA-351215
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
S-adenosyl 3-(methylsulfanyl)propylamine + putrescine => S-methyl-5'-thioadenosine + spermidine + H(+)
ReviewStatus
4/5
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Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Spermidine synthase (SRM) carries out the final step of spermidine biosynthesis, transferring an aminopropyl group from decarboxylated S-adenosylmethionine (dc-AdoMet) to putrescine to form spermidine (SPM) (Myohanen et al. 1991; Wu et al. 2007).
Literature References
PubMed ID Title Journal Year
2069720 Human spermidine synthase gene: structure and chromosomal localization

Myöhänen, S, Kauppinen, L, Wahlfors, J, Alhonen, L, Jänne, J

DNA Cell Biol 1991
17585781 Structure and mechanism of spermidine synthases

Wu, H, Min, J, Ikeguchi, Y, Zeng, H, Dong, A, Loppnau, P, Pegg, AE, Plotnikov, AN

Biochemistry 2007
Participants
Input
Output
Participates
as an event of
Catalyst Activity

spermidine synthase activity of SRM [cytosol]

Physical Entity
SRM [cytosol] (Homo sapiens)
Activity
spermidine synthase activity (GO:0004766)
Orthologous Events
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Bos taurus)
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Caenorhabditis elegans)
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Canis familiaris)
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Dictyostelium discoideum)
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Drosophila melanogaster)
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Gallus gallus)
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Mus musculus)
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Plasmodium falciparum)
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Rattus norvegicus)
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Saccharomyces cerevisiae)
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Schizosaccharomyces pombe)
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Sus scrofa)
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Xenopus tropicalis)
Cross References
RHEA
Rhea
Authored
Gopinathrao, G  (2008-05-21)
Reviewed
D'Eustachio, P  (2008-06-12)
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