Reactome | Spermidine => N-acetylated spermidine

Spermidine => N-acetylated spermidine

Stable Identifier

R-HSA-351208

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

spermidine + acetyl-CoA => N(1)-acetylspermidine + CoA + H(+)

ReviewStatus

4/5

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Spermidine/spermine N1-acetyltransferase (SAT1, also known as diamine acetyltransferase 1) acetylates spermidine (SPM) to yield N-acetylspermidine (NASPM). This is the rate-limiting step in polyamine catabolism (Casero et al. 1991; Fogel-Petrovic et al. 1993).

Literature References

PubMed ID	Title	Journal	Year
8360194	Polyamine and polyamine analog regulation of spermidine/spermine N1-acetyltransferase in MALME-3M human melanoma cells Fogel-Petrovic, M, Shappell, NW, Bergeron, RJ, Porter, CW	J Biol Chem	1993
1985966	Isolation and characterization of a cDNA clone that codes for human spermidine/spermine N1-acetyltransferase Casero RA, Jr, Celano, P, Ervin, SJ, Applegren, NB, Wiest, L, Pegg, AE	J Biol Chem	1991