Reactome | Interconversion of polyamines

Interconversion of polyamines

Stable Identifier

R-HSA-351200

Type

Pathway

Species

Homo sapiens

Compartment

cytosol, peroxisomal matrix

ReviewStatus

5/5

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The reactions catalyzed by aminopropyl-transferases annotated above are generally irreversible. But spermine and spermidine can be recycled respectively into spermidine and putrescine. These events require the formation of N-acetylated intermediates, N1-acetylspermine and N1-acetylspermidine catalyzed by a cytosolic acetyl-CoA:spermidine/spermine N1-acetyl-tranferase (SSAT) enzyme.
Subsequently, polyamine-oxidase (PAO), a FAD enzyme present in the peroxysomes, yields a polyamine with release of an aldehyde (3-acetamindopropanal) and H2O2.
In addition, SMOX, a FAD-dependent, polyamine oxidase (PAOh1/SMO) that can efficiently use spermine as a substrate and is involved in interconversion reactions.

Literature References

PubMed ID	Title	Journal	Year
11564948	Polyamine metabolism revisited Medina, MA, Urdiales, JL, Sánchez-Jiménez, F	Eur J Gastroenterol Hepatol	2001
15221502	Catabolism of polyamines Seiler, N	Amino Acids	2004
12686127	Decarboxylases involved in polyamine biosynthesis and their inactivation by nitric oxide Hillary, RA, Pegg, AE	Biochim Biophys Acta	2003
15784477	Polyamines: metabolism and implications in human diseases de Bandt, JP, Cynober, L, Moinard, C	Clin Nutr	2005