beta-catenin is replaced by repression complexes at the promoter

Stable Identifier
R-HSA-3361751
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Displacement of the APC:CTBP:beta-catenin:betaTrCP complex allows subsequent recruitment of TLE:HDAC1 to TCF/LEF, re-establishing a repression complex (Sierra et al, 2006)

Literature References
PubMed ID Title Journal Year
16510874 The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes

Sierra, J, Yoshida, T, Joazeiro, CA, Jones, KA

Genes Dev. 2006
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created