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TCF/LEF:CTNNB1:APC:CTBP:BTRC [nucleoplasm]
Stable Identifier
R-HSA-3361754
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Deactivation of the beta-catenin transactivating complex (Homo sapiens)
APC promotes disassembly of beta-catenin transactivation complex (Homo sapiens)
TCF/LEF:CTNNB1:APC:CTBP:BTRC [nucleoplasm] (Homo sapiens)
beta-catenin is replaced by repression complexes at the promoter (Homo sapiens)
TCF/LEF:CTNNB1:APC:CTBP:BTRC [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
16510874
The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes
Yoshida, T
,
Jones, KA
,
Sierra, J
,
Joazeiro, CA
Genes Dev.
2006
Participants
components
APC [nucleoplasm]
(Homo sapiens)
BTRC [nucleoplasm]
(Homo sapiens)
CTBP1 [nucleoplasm]
(Homo sapiens)
CTNNB1 [nucleoplasm]
(Homo sapiens)
TCF/LEF [nucleoplasm]
(Homo sapiens)
Participates
as an output of
APC promotes disassembly of beta-catenin transactivation complex (Homo sapiens)
as an input of
beta-catenin is replaced by repression complexes at the promoter (Homo sapiens)
Inferred To
TCF/LEF:CTNNB1:APC:CTBP:BTRC [nucleoplasm]
(Bos taurus)
TCF/LEF:CTNNB1:APC:CTBP:BTRC [nucleoplasm]
(Caenorhabditis elegans)
TCF/LEF:CTNNB1:APC:CTBP:BTRC [nucleoplasm]
(Canis familiaris)
TCF/LEF:CTNNB1:APC:CTBP:BTRC [nucleoplasm]
(Drosophila melanogaster)
TCF/LEF:CTNNB1:APC:CTBP:BTRC [nucleoplasm]
(Gallus gallus)
TCF/LEF:CTNNB1:APC:CTBP:BTRC [nucleoplasm]
(Mus musculus)
TCF/LEF:CTNNB1:APC:CTBP:BTRC [nucleoplasm]
(Rattus norvegicus)
TCF/LEF:CTNNB1:APC:CTBP:BTRC [nucleoplasm]
(Sus scrofa)
TCF/LEF:CTNNB1:APC:CTBP:BTRC [nucleoplasm]
(Xenopus tropicalis)
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