Reactome | TAS2R19 [plasma membrane]

TAS2R19 [plasma membrane]

Stable Identifier

R-HSA-3299625

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Taste receptor type 2 member 19, T2R19_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R19 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R19 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R19 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R19 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R19 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R19 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
      - T2Rs bind bitter-tasting compounds (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R19 [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R19 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P59542 TAS2R19

Gene Names

TAS2R19, TAS2R23, TAS2R48

Chain

chain:1-299

Reference Genes

BioGPS Gene:259294 TAS2R19

COSMIC (genes):TAS2R19 TAS2R19

CTD Gene:259294 TAS2R19

dbSNP Gene:259294 TAS2R19

ENSEMBL:ENSG00000212124 TAS2R19

HGNC:19108 TAS2R19

KEGG:hsa:259294 TAS2R19

Monarch:259294 TAS2R19

NCBI Gene:259294 TAS2R19

OMIM:613961 TAS2R19

UCSC:P59542 TAS2R19

Reference Transcript

RefSeq:NM_176888.2 TAS2R19

Other Identifiers

11738326_at

16761514

259294

3444494

7961287

ADDON002758.hg

A_23_P340308

GE470803

GO:0004930

GO:0005515

GO:0005886

GO:0007186

GO:0016020

GO:0033038

GO:0050877

GO:0050909

GO:0060089

HMNXSV003013190

ILMN_1694485

PH_hs_0034927

TC12001238.hg

Participates

as a member of

TAS2Rs [plasma membrane] (Homo sapiens)

Inferred To

TAS2R46 [plasma membrane] (Bos taurus)

Tas2r120 [plasma membrane] (Mus musculus)

Tas2r120 [plasma membrane] (Rattus norvegicus)

Tas2r136 [plasma membrane] (Mus musculus)

Tas2r136 [plasma membrane] (Rattus norvegicus)

t2r14 [plasma membrane] (Xenopus tropicalis)

CAFA-T2R43 [plasma membrane] (Canis familiaris)

t2r2 [plasma membrane] (Xenopus tropicalis)

Homologues of TAS2R19 [plasma membrane] (Bos taurus)

Homologues of TAS2R19 [plasma membrane] (Canis familiaris)

Homologues of TAS2R19 [plasma membrane] (Danio rerio)

Homologues of TAS2R19 [plasma membrane] (Gallus gallus)

Homologues of TAS2R19 [plasma membrane] (Mus musculus)

Homologues of TAS2R19 [plasma membrane] (Rattus norvegicus)

Homologues of TAS2R19 [plasma membrane] (Xenopus tropicalis)

LOC100154902 [plasma membrane] (Sus scrofa)

t2r3 [plasma membrane] (Xenopus tropicalis)

TAS2R7 [plasma membrane] (Gallus gallus)

tas2r200.1 [plasma membrane] (Danio rerio)

tas2r7 [plasma membrane] (Xenopus tropicalis)

TAS2R40 [plasma membrane] (Gallus gallus)

LOC100682759 [plasma membrane] (Canis familiaris)

t2r15 [plasma membrane] (Xenopus tropicalis)

tas2r4 [plasma membrane] (Xenopus tropicalis)

LOC782957 [plasma membrane] (Bos taurus)

TAS2R19 [plasma membrane] (Bos taurus)

tas2r200.2 [plasma membrane] (Danio rerio)

LOC101747503 [plasma membrane] (Gallus gallus)

Cross References

RefSeq

NP_795369.1

Guide to Pharmacology - Targets

670

ENSEMBL

ENSP00000375091, ENST00000390673, ENSP00000461533, ENST00000573562

OpenTargets

ENSG00000212124

HPA

ENSG00000212124-TAS2R19

PRO

P59542

Pharos - Targets

P59542

GlyGen

P59542

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P15151 PVR	1	PVR [plasma membrane] (R-HSA-420600)	0.556	3
UniProt:Q8N4V1 MMGT1	1	MMGT1 [Golgi membrane] (R-HSA-5216137)	0.556	3
UniProt:O15173 PGRMC2	4	PGRMC2 [nuclear envelope] (R-HSA-9707674) PGRMC2 [nucleoplasm] (R-HSA-9707859) PGRMC2 [endoplasmic reticulum membrane] (R-HSA-9714349) PGRMC2 [endosome membrane] (R-HSA-9715090)	0.556	3