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NLRP4 [cytosol]
Stable Identifier
R-HSA-3249366
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
NACHT, LRR and PYD domains-containing protein 4
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
Regulation of innate immune responses to cytosolic DNA (Homo sapiens)
DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Homo sapiens)
NLRP4 [cytosol] (Homo sapiens)
NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Homo sapiens)
NLRP4 [cytosol] (Homo sapiens)
DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1 (Homo sapiens)
NLRP4 [cytosol] (Homo sapiens)
NLRP4:DTX4:dsDNA:ZBP1:pS-172-TBK1 [cytosol] (Homo sapiens)
NLRP4 [cytosol] (Homo sapiens)
NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Homo sapiens)
NLRP4 [cytosol] (Homo sapiens)
NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Homo sapiens)
NLRP4 [cytosol] (Homo sapiens)
NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1 (Homo sapiens)
NLRP4 [cytosol] (Homo sapiens)
NLRP4:DTX4:dsDNA:ZBP1:pS-172-TBK1 [cytosol] (Homo sapiens)
NLRP4 [cytosol] (Homo sapiens)
STING mediated induction of host immune responses (Homo sapiens)
IRF3-mediated induction of type I IFN (Homo sapiens)
IRF3 is phosphorylated by TBK1 (Homo sapiens)
NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Homo sapiens)
NLRP4 [cytosol] (Homo sapiens)
ZBP1(DAI) mediated induction of type I IFNs (Homo sapiens)
IRF3 mediated activation of type 1 IFN (Homo sapiens)
Phosphorylation and release of IRF3 (Homo sapiens)
NLRP4:DTX4:dsDNA:ZBP1:pS-172-TBK1 [cytosol] (Homo sapiens)
NLRP4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96MN2 NLRP4
Gene Names
NLRP4, NALP4, PAN2, PYPAF4, RNH2
Chain
chain:1-994
Reference Genes
BioGPS Gene:147945 NLRP4
COSMIC (genes):NLRP4 NLRP4
COSMIC (genes):PAN2 RDH14
CTD Gene:147945 NLRP4
dbSNP Gene:147945 NLRP4
ENSEMBL:ENSG00000160505 NLRP4
HGNC:22943 NLRP4
KEGG:hsa:147945 NLRP4
Monarch:147945 NLRP4
NCBI Gene:147945 NLRP4
OMIM:609645 NLRP4
UCSC:Q96MN2 NLRP4
Reference Transcript
RefSeq:NM_134444.4 NLRP4
Other Identifiers
11755596_a_at
147945
16865789
242334_PM_at
242334_at
3842457
3842458
3842459
3842460
3842461
3842463
3842464
3842465
3842466
3842467
3842468
3842470
3842471
3842472
3842473
3842475
3842476
3842477
3842478
3842479
3842480
42793_at
8031576
A_14_P127519
A_23_P164966
A_33_P3406047
GE80604
GO:0005515
GO:0005524
GO:0005737
GO:0005829
GO:0006954
GO:0045824
GO:0050727
GO:0060090
HMNXSV003010301
Hs.164851.0.A1_3p_at
ILMN_1746820
PH_hs_0032797
TC19000913.hg
Participates
as an input of
NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1 (Homo sapiens)
NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Homo sapiens)
as an output of
DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1 (Homo sapiens)
DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Homo sapiens)
as a component of
NLRP4:DTX4:dsDNA:ZBP1:pS-172-TBK1 [cytosol] (Homo sapiens)
NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Homo sapiens)
Inferred To
LOC108644478 [cytosol]
(Xenopus tropicalis)
Ghost homologue of NLRP4 [cytosol]
(Bos taurus)
LOC100491706 [cytosol]
(Xenopus tropicalis)
Homologues of NLRP4 [cytosol]
(Xenopus tropicalis)
Nlrp4 [cytosol]
(Rattus norvegicus)
NLRP4 [cytosol]
(Danio rerio)
NLRP4 [cytosol]
(Gallus gallus)
NLRP4 [cytosol]
(Mus musculus)
NLRP4 [cytosol]
(Sus scrofa)
Cross References
Guide to Pharmacology - Targets
1771
ENSEMBL
ENST00000301295
,
ENST00000587891
,
ENSP00000465463
,
ENSP00000301295
,
ENSG00000160505
OpenTargets
ENSG00000160505
GeneCards
NLRP4
HPA
ENSG00000160505-NLRP4
PRO
Q96MN2
Pharos - Targets
Q96MN2
HMDB Protein
HMDBP12751
PDB
4EWI
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