DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1

Stable Identifier
R-HSA-3249386
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

NLRP4 regulate the host immune responses by recruiting E3 ubiquitin-protein ligase DTX4 to the kinase TBK1. DTX4 promotes K48-linked ubiquitination of TBK1 resulting in the degradation of TBK1 and downregulation of IFN signaling (Cui J et al. 2012).

Literature References
PubMed ID Title Journal Year
22388039 NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4

Cui, J, Li, Y, Zhu, L, Liu, D, Songyang, Z, Wang, HY, Wang, RF

Nat. Immunol. 2012
Participants
Participates
Catalyst Activity

ubiquitin-protein transferase activity of NLRP4:DTX4:dsDNA:ZBP1:pS-172-TBK1 [cytosol]

Authored
Reviewed
Created
Cite Us!