DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3

Stable Identifier
R-HSA-8948709
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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NLRP4 regulate the host immune responses by recruiting E3 ubiquitin-protein ligase DTX4 to the kinase TBK1. DTX4 promotes K48-linked ubiquitination of TBK1 resulting in the degradation of TBK1 and downregulation of IFN signaling (Cui J et al. 2012).

Literature References
PubMed ID Title Journal Year
22388039 NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4

Cui, J, Li, Y, Zhu, L, Liu, D, Songyang, Z, Wang, HY, Wang, RF

Nat. Immunol. 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created