STING binds cyclic GMP-AMP

Stable Identifier
Reaction [omitted]
Homo sapiens
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Direct binding assays with radiolabeled substrate showed that the association of STING protein (residues 139-379) with [32P]-cGAMP was inhibited in the presence of competing cold cGAMP, c-di-GMP or c-di-AMP, suggesting that the cGAMP binding sites on STING might overlap with those that interact with c-di-GMP and c-di-AMP (Wu J et al.2013). Indeed, mutations of several residues that were shown to participate in the binding of STING to c-di-GMP, including S161Y, Y240S and N242A, also impaired the binding of STING to cGAMP (Yin Q et al. 2012; Wu J et al.2013). Structural study revealed that cGAMP generated by cGAS contains G(2',5')pA and A(3',5')pG phosphodiester linkages, which is distinct from bacterial 3',5' cyclic dinucleotides (Gao P et al. 2013).

Literature References
PubMed ID Title Journal Year
23258412 Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA

Chen, C, Chen, ZJ, Du, F, Sun, L, Wu, J, Shi, H, Chen, X

Science 2013
23258413 Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

Chen, ZJ, Du, F, Wu, J, Sun, L, Chen, X

Science 2013
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