Cytosolic sensors of pathogen-associated DNA

Stable Identifier
Homo sapiens
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Presence of pathogen-associated DNA in cytosol induces type I IFN production. Several intracellular receptors have been implicated to some degree. These include DNA-dependent activator of interferon (IFN)-regulatory factors (DAI) (also called Z-DNA-binding protein 1, ZBP1), absent in melanoma 2 (AIM2), RNA polymerase III (Pol III), IFN-inducible protein IFI16, leucine-rich repeat flightless interacting protein-1 (LRRFIP1), DEAH-box helicases (DHX9 and DHX36), DEAD-box helicase DDX41, meiotic recombination 11 homolog A (MRE11), DNA-dependent protein kinase (DNA-PK), cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING).

Detection of cytosolic DNA requires multiple and possibly redundant sensors leading to activation of the transcription factor NF-kappaB and TBK1-mediated phosphorylation of the transcription factor IRF3. Cytosolic DNA also activates caspase-1-dependent maturation of the pro-inflammatory cytokines interleukin IL-1beta and IL-18. This pathway is mediated by AIM2.

Literature References
PubMed ID Title Journal Year
21533068 Innate immune sensing of DNA

Sharma, S, Fitzgerald, KA

PLoS Pathog 2011
23706668 Immune Sensing of DNA

Paludan, SR, Bowie, AG

Immunity 2013
23706667 Cytosolic Sensing of Viruses

Goubau, D, Deddouche, S, Reis e Sousa, C

Immunity 2013
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Event Information
Orthologous Events
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