Maturation of HIV Virion

Stable Identifier
R-HSA-3139027
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The proteolytic events that cleave Gag and Gag-Pro-Pol are well characterized, but the event that triggers the protease is not well characterized. The PRGag, that is assembled in the immature virion weakly dimerizes, once PR is cleaved from the proprotein PR dimerizes and becomes an efficient protease. This assembly step may be part of the switch. Once the protease becomes active in the immature virion MA, CA, SP1, NC, SP2, P6, PR, RT, and IN are produced. This event, the production of these fragments would be the switch from immature to mature.

Literature References
PubMed ID Title Journal Year
23266279 HIV Gag polyprotein: processing and early viral particle assembly

Bell, NM, Lever, AM

Trends Microbiol. 2013
22762019 HIV-1 Assembly, Budding, and Maturation

Sundquist, WI, Kräusslich, HG

Cold Spring Harb Perspect Med 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
peptidase activity of GAG-POL Polyprotein (P04585) [extracellular region]
Physical Entity
Activity
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 HIV infection
Authored
Reviewed
Created
Cite Us!