Reactome | Beta-catenin enhances association of IRF3 with CBP/p300

Beta-catenin enhances association of IRF3 with CBP/p300

Stable Identifier

R-HSA-3134883

Type

Reaction

Species

Homo sapiens

Compartment

nucleoplasm

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Beta-catenin enhances association of IRF3 with CBP/p300

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Beta-catenin increases IFN-beta expression by binding to the C-terminal domain of the transcription factor IRF3 and recruiting the acetyltransferase p300 to the IFN-beta enhanceosome via IRF3.

Literature References

PubMed ID	Title	Journal	Year
20453844	The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway Wen, M, Rui, Y, Liu, X, Yang, P, Cao, X, Zheng, Y, An, H	Nat. Immunol.	2010
9541017	Involvement of the IRF family transcription factor IRF-3 in virus-induced activation of the IFN-beta gene Sato, M, Hata, N, Oda, E, Taniguchi, T, Tanaka, N	FEBS Lett	1998