Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
GIF [extracellular region]
Stable Identifier
R-HSA-2980918
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Gastric intrinsic factor, IF_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Defects in vitamin and cofactor metabolism (Homo sapiens)
Defects in cobalamin (B12) metabolism (Homo sapiens)
Defective AMN causes hereditary megaloblastic anemia 1 (Homo sapiens)
Defective AMN does not transport GIF:Cbl (Homo sapiens)
GIF:Cbl [extracellular region] (Homo sapiens)
GIF [extracellular region] (Homo sapiens)
Defective CUBN causes hereditary megaloblastic anemia 1 (Homo sapiens)
Defective CUBN does not transport GIF:Cbl (Homo sapiens)
GIF:Cbl [extracellular region] (Homo sapiens)
GIF [extracellular region] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Homo sapiens)
CUBN:AMN binds GIF:Cbl (Homo sapiens)
CUBN:AMN:GIF:Cbl [plasma membrane] (Homo sapiens)
GIF:Cbl [extracellular region] (Homo sapiens)
GIF [extracellular region] (Homo sapiens)
GIF:Cbl [extracellular region] (Homo sapiens)
GIF [extracellular region] (Homo sapiens)
CUBN:AMN transports extracellular GIF:Cbl to endosome (Homo sapiens)
CUBN:AMN:GIF:Cbl [plasma membrane] (Homo sapiens)
GIF:Cbl [extracellular region] (Homo sapiens)
GIF [extracellular region] (Homo sapiens)
GIF binds Cbl (Homo sapiens)
GIF [extracellular region] (Homo sapiens)
GIF:Cbl [extracellular region] (Homo sapiens)
GIF [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P27352 CBLIF
Gene Names
CBLIF, GIF, IFMH
Chain
signal peptide:1-18, chain:19-417
Reference Genes
BioGPS Gene:2694 CBLIF
COSMIC (genes):CBLIF CBLIF
CTD Gene:2694 CBLIF
dbSNP Gene:2694 CBLIF
ENSEMBL:ENSG00000134812 GIF
HGNC:4268 CBLIF
KEGG Gene (Homo sapiens):2694 CBLIF
Monarch:2694 CBLIF
NCBI Gene:2694 CBLIF
OMIM:609342 CBLIF
UCSC:P27352 CBLIF
Reference Transcript
RefSeq:NM_005142.2 CBLIF
Other Identifiers
0005910593
11733983_a_at
11748336_a_at
16738786
207033_at
2694
32470_at
3374875
3374876
3374879
3374880
3374881
3374884
3374885
3374886
3374887
3374888
3374889
7948433
A_23_P52974
GE80514
GO:0003674
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005764
GO:0005768
GO:0005773
GO:0005886
GO:0005902
GO:0006810
GO:0006811
GO:0006824
GO:0008150
GO:0009235
GO:0015889
GO:0016324
GO:0031410
GO:0031419
GO:0043202
GO:0043226
GO:0044281
GO:0051186
ILMN_1731547
M63154_at
PH_hs_0006064
TC11001836.hg
g4826743_3p_at
Participant Of
input
GIF binds Cbl
hasComponent
GIF:Cbl [extracellular region]
Other forms of this molecule
GIF S27Cfs*23 [extracellular region]
GIF [endosome]
GIF [lysosomal lumen]
Inferred To
CBLIF [extracellular region] (Bos taurus)
GIF [extracellular region] (Drosophila melanogaster)
GIF [extracellular region] (Sus scrofa)
GIF [extracellular region] (Xenopus tropicalis)
tcnbb [extracellular region] (Danio rerio)
tcn2 [extracellular region] (Danio rerio)
Homologues of GIF [extracellular region] (Danio rerio)
Cblif [extracellular region] (Mus musculus)
Cblif [extracellular region] (Rattus norvegicus)
Cross References
RefSeq
NP_005133.2
OpenTargets
ENSG00000134812
GeneCards
P27352
HPA
ENSG00000134812-GIF
Ensembl
ENSP00000257248
,
ENSG00000134812
,
ENST00000257248
PRO
P27352
Orphanet
16124
HMDB Protein
HMDBP01997
PDB
2PMV
,
2CKT
,
3KQ4
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O60494 CUBN
5
CUBN [cytosol]
(R-HSA-350162)
CUBN P1297L [plasma membrane]
(R-HSA-3296479)
CUBN [lysosomal lumen]
(R-HSA-350088)
CUBN [endosome membrane]
(R-HSA-3000135)
CUBN [plasma membrane]
(R-HSA-264843)
0.558
2
UniProt:Q8TBB6 S7A14
0.556
3
UniProt:A1A5C7-2 SLC22A23
0.556
3
UniProt:P30825 SLC7A1
1
SLC7A1 [plasma membrane]
(R-HSA-375771)
0.556
3
UniProt:O15552 FFAR2
1
FFAR2 [plasma membrane]
(R-HSA-443944)
0.556
3
UniProt:Q96Q45-2 TMEM237
0.556
3
UniProt:Q9UKG4 SLC13A4
1
SLC13A4 [plasma membrane]
(R-HSA-433098)
0.556
3
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text