Reactome | CBLIF [extracellular region]

CBLIF [extracellular region]

Stable Identifier

R-HSA-2980918

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Gastric intrinsic factor, IF_HUMAN

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External Reference Information

External Reference

UniProt:P27352 CBLIF

Gene Names

CBLIF, GIF, IFMH

Chain

signal peptide:1-18, chain:19-417

Reference Genes

BioGPS Gene:2694 CBLIF

COSMIC (genes):CBLIF CBLIF

CTD Gene:2694 CBLIF

dbSNP Gene:2694 CBLIF

ENSEMBL:ENSG00000134812.8 CBLIF

HGNC:4268 CBLIF

KEGG Gene (Homo sapiens):2694 CBLIF

Monarch:2694 CBLIF

NCBI Gene:2694 CBLIF

OMIM:609342 CBLIF

UCSC:P27352 CBLIF

Reference Transcript

RefSeq:NM_005142.2 CBLIF

Other Identifiers

0005910593

11733983_a_at

11748336_a_at

16738786

207033_PM_at

207033_at

2694

32470_at

3374875

3374876

3374879

3374880

3374881

3374884

3374885

3374886

3374887

3374888

3374889

7948433

A_23_P52974

GE80514

GO:0005515

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005764

GO:0005768

GO:0005773

GO:0005886

GO:0005902

GO:0006811

GO:0006824

GO:0015889

GO:0016324

GO:0031410

GO:0031419

GO:0043202

GO:0043226

GO:0055085

GO:0140355

HMNXSV003042265

ILMN_1731547

M63154_at

PH_hs_0006064

TC11001836.hg

g4826743_3p_at

Participates

as an input of

CBLIF binds RCbl (Homo sapiens)

as a component of

CBLIF:RCbl [extracellular region] (Homo sapiens)

Other forms of this molecule

CBLIF S27Cfs*23 [extracellular region]

CBLIF [lysosomal lumen]

Inferred To

CBLIF [extracellular region] (Bos taurus)

CBLIF [extracellular region] (Canis familiaris)

CBLIF [extracellular region] (Drosophila melanogaster)

CBLIF [extracellular region] (Mus musculus)

CBLIF [extracellular region] (Rattus norvegicus)

CBLIF [extracellular region] (Sus scrofa)

cblif [extracellular region] (Xenopus tropicalis)

si:ch211-102c2.6 [extracellular region] (Danio rerio)

Cross References

RefSeq

NP_005133.2

OpenTargets

ENSG00000134812

HPA

ENSG00000134812-CBLIF

GeneCards

P27352

Ensembl

ENST00000257248, ENSP00000257248, ENSG00000134812

PRO

P27352

Pharos - Targets

P27352

Orphanet

16124

HMDB Protein

HMDBP01997

PDB

2PMV, 3KQ4

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60494 CUBN	4	CUBN P1297L [plasma membrane] (R-HSA-3296479) CUBN [cytosol] (R-HSA-350162) CUBN [lysosomal lumen] (R-HSA-350088) CUBN [plasma membrane] (R-HSA-264843)	0.558	2
UniProt:Q8TBB6 S7A14			0.556	3
UniProt:A1A5C7-2 SLC22A23			0.556	3
UniProt:P30825 SLC7A1	1	SLC7A1 [plasma membrane] (R-HSA-375771)	0.556	3
UniProt:O15552 FFAR2	1	FFAR2 [plasma membrane] (R-HSA-443944)	0.556	3
UniProt:Q9UKG4 SLC13A4	1	SLC13A4 [plasma membrane] (R-HSA-433098)	0.556	3
UniProt:Q96Q45-2 TMEM237			0.556	3