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TCN1 [extracellular region]
Stable Identifier
R-HSA-2980920
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Transcobalamin-1, TCO1_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of specific granule lumen proteins (Homo sapiens)
Specific granule lumen proteins [extracellular region] (Homo sapiens)
TCN1 [extracellular region] (Homo sapiens)
Exocytosis of tertiary granule lumen proteins (Homo sapiens)
Tertiary granule lumen proteins [extracellular region] (Homo sapiens)
TCN1 [extracellular region] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Homo sapiens)
Transport of RCbl within the body (Homo sapiens)
TCN1 binds correnoids in the circulation (Homo sapiens)
TCN1 [extracellular region] (Homo sapiens)
TCN1:correnoid [extracellular region] (Homo sapiens)
TCN1 [extracellular region] (Homo sapiens)
Uptake of dietary cobalamins into enterocytes (Homo sapiens)
Pancreatic proteases degrade TCN1:RCbl (Homo sapiens)
TCN1:RCbl [extracellular region] (Homo sapiens)
TCN1 [extracellular region] (Homo sapiens)
TCN1 binds RCbl (Homo sapiens)
TCN1 [extracellular region] (Homo sapiens)
TCN1:RCbl [extracellular region] (Homo sapiens)
TCN1 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20061 TCN1
Gene Names
TCN1, TC1
Chain
signal peptide:1-23, chain:24-433
Reference Genes
BioGPS Gene:6947 TCN1
COSMIC (genes):TCN1 TCN1
CTD Gene:6947 TCN1
dbSNP Gene:6947 TCN1
ENSEMBL:ENSG00000134827 TCN1
HGNC:11652 TCN1
KEGG:hsa:6947 TCN1
Monarch:6947 TCN1
NCBI Gene:6947 TCN1
OMIM:189905 TCN1
UCSC:P20061 TCN1
Reference Transcript
RefSeq:NM_001062.3 TCN1
Other Identifiers
11726124_at
16738803
205513_PM_at
205513_at
3374891
3374892
3374893
3374894
3374895
3374896
3374897
3374898
3374899
3374900
3374901
3374902
3374903
35919_at
6947
7948444
A_23_P64372
GE57524
GO:0005515
GO:0005576
GO:0005615
GO:0006824
GO:0015889
GO:0031419
GO:0035580
GO:0055085
GO:0140313
GO:0140355
GO:1904724
HMNXSV003057868
ILMN_1768469
J05068_at
PH_hs_0000268
TC11001837.hg
g4507406_3p_at
Participates
as a component of
TCN1:correnoid [extracellular region] (Homo sapiens)
TCN1:RCbl [extracellular region] (Homo sapiens)
as an input of
TCN1 binds correnoids in the circulation (Homo sapiens)
TCN1 binds RCbl (Homo sapiens)
as a member of
Tertiary granule lumen proteins [extracellular region] (Homo sapiens)
Specific granule lumen proteins [extracellular region] (Homo sapiens)
Other forms of this molecule
TCN1 [tertiary granule lumen]
TCN1 [specific granule lumen]
Inferred To
TCN1 [extracellular region]
(Bos taurus)
TCN1 [extracellular region]
(Canis familiaris)
TCN1 [extracellular region]
(Drosophila melanogaster)
TCN1 [extracellular region]
(Sus scrofa)
TCN1 [extracellular region]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001053.2
ENSEMBL
ENSP00000257264
,
ENST00000257264
OpenTargets
ENSG00000134827
HPA
ENSG00000134827-TCN1
PRO
P20061
Pharos - Targets
P20061
HMDB Protein
HMDBP01996
PDB
4KKI
,
4KKJ
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8WXH2 JPH3
0.556
3
UniProt:Q9H8H2 DDX31
0.527
2
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